Results 121 to 130 of about 775 (254)

Western Diet Combined With Chemical Induction: A Strategy for Rapid Development of MASLD Pathology in Mice

iNew Medicine, EarlyView.
ABSTRACT The molecular mechanisms underlying the development of metabolic‐dysfunction‐associated steatotic liver disease (MASLD) are essential for developing appropriate treatments. The purpose of this study was to establish an MASLD model in mice with rapid and consistent progression.
Ting‐Ting Chen, Nan Li, Shuo Wang, Miao Sun, Rui Yang, Shi‐Hao Zhang, Xiao‐Lei Li, Chen Dong, Ke‐Yuan Chen, Wu‐Yi Sun, Na Zhou   +10 more
wiley   +1 more source

A study on turbulence characteristics of a rectangular three-dimensional wall jet in a confined space using particle image velocimetry. [PDF]

PLoS One
Zhang X, Liu H.
europepmc   +1 more source

The Information Content of the 1999 Announcement of Funds from Operations (FFO) Changes for Real Estate Investment Trusts [PDF]

This study examines the market response to the 1999 announcement of a change in accounting for Funds from Operations (FFO) for Real Estate Investment Trusts (REITs).
Robert A. Van Ness, Richard L. Ott, Eric J. Higgins   +2 more
core  

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Population panmixia of the pelagic shrimp Lucensosergia lucens between Japanese and Taiwanese waters in the western North Pacific. [PDF]

Sci Rep
Hirai J, Hsiao ST, Yeh HM, Nishikawa J.
europepmc   +1 more source

CHARACTERISTICS OF NONAERATED SKIMMING FLOWS IN STEPPED CHANNELS

Journal of Japan Society of Civil Engineers, Ser. B1 (Hydraulic Engineering), 2016
Yuki YAMAMOTO, Masayuki TAKAHASHI, Iwao OHTSU   +2 more
openaire   +2 more sources

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Evaluation of advanced AI models for accurate prediction and uncertainty analysis of aeration inception in hydrofoil-crested stepped spillways. [PDF]

Sci Rep
Nejatipour P, Kiani B, Salavat SK, Atajanova S, Xudaynazarov E, Matchanova B, Afaridegan E.   +6 more
europepmc   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Giving Up

Journal of Applied Philosophy, EarlyView.
ABSTRACT Philosophical accounts of long‐term goals focus predominantly on the rationality of perseverance, examining when agents should persist despite evidence of failure. Arguably, these accounts consider that giving up is devoid of value. Conversely, this article argues that giving up has a different epistemic function: generating information about ...
Mario I. Juarez‐Garcia
wiley   +1 more source