Results 71 to 80 of about 6,156,020 (403)

Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris

Nature Communications
Pityriasis rubra pilaris (PRP) is an inflammatory papulosquamous dermatosis, characterized by hyperkeratotic follicular papules and erythematous desquamative plaques. The precise pathogenic mechanism underlying PRP remains incompletely understood. Herein,
Peidian Shi, Wenjie Chen, Xinxing Lyu, Zhenzhen Wang, Wenchao Li, Fengming Jia, Chunzhi Zheng, Tingting Liu, Chuan Wang, Yuan Zhang, Zihao Mi, Yonghu Sun, Xuechao Chen, Shengli Chen, Guizhi Zhou, Yongxia Liu, Yingjie Lin, Fuxiang Bai, Qing Sun, Monday O. Ogese, Qiang Yu, Jianjun Liu, Hong Liu, Furen Zhang   +23 more
doaj   +1 more source

A rare case of acral persistent papular mucinosis

Clinical Case Reports, 2020
In patients with asymptomatic papules of hands and feet, a clinical differential of acral persistent papular mucinosis should be thought of.
Joseph Jia‐Hong Toh, Nicholas Seng-Geok Goh, Ding Yuan Wang   +2 more
doaj   +1 more source

On the tear resistance of skin. [PDF]

, 2015
Tear resistance is of vital importance in the various functions of skin, especially protection from predatorial attack. Here, we mechanistically quantify the extreme tear resistance of skin and identify the underlying structural features, which lead to ...
Gludovatz, Bernd, Meyers, Marc A, Ritchie, Robert O, Schaible, Eric, Sherman, Vincent R, Stewart, Polite, Yang, Wen   +6 more
core   +2 more sources

Sensitive skin [PDF]

Journal of the European Academy of Dermatology and Venereology, 2016
AbstractSensitive skin is a clinical condition defined by the self‐reported facial presence of different sensory perceptions, including tightness, stinging, burning, tingling, pain and pruritus. Sensitive skin may occur in individuals with normal skin, with skin barrier disturbance, or as a part of the symptoms associated with facial dermatoses such as
L, Misery, K, Loser, S, Ständer
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Cross-cultural effects of color, but not morphological masculinity, on perceived attractiveness of men's faces [PDF]

, 2012
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 ElsevierMuch attractiveness research has focused on face shape.
Adamo, Adamo, Brooks, Brown, Bulygina, Central Intelligence Agency, Cunningham, David I. Perrett, DeBruine, DeBruine, DeBruine, Dowling, Fink, Fink, Frederick, Goodall, Gower, Hamilton, Hill, Hong, Ian D. Stephen, Ian S. Penton-Voak, Isabel M.L. Scott, Johnston, Jones, Jones, Kokko, Komori, Koutsos, Little, Lozano, Martinkauppi, Matts, Neave, Nicholas Pound, O'Higgins, O'Toole, Paxton, Penton-Voak, Penton-Voak, Penton-Voak, Penton-Voak, Penton-Voak, Penton-Voak, Perrett, Perrett, Pound, Puts, Puts, Rhodes, Rhodes, Rhodes, Rhodes, Robins, Rohlf, Scarbrough, Scott, Scott, Shepherd, Stahl, Stephan, Stephen, Stephen, Stephen, Stephen, Tiddeman, Valentine, Vinet Coetzee, Wilcox, Zihlman   +69 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

A prospective observational study of mycophenolate mofetil treatment in progressive diffuse cutaneous systemic sclerosis of recent onset. [PDF]

, 2012
OBJECTIVE: A prospective observational study of mycophenolate mofetil (MMF) treatment in patients with diffuse progressive cutaneous systemic sclerosis (SSc) of recent onset.
Jimenez, Sergio A., Lee, MD, Jason B., Mendoza, MD, Fabian A., Nagle, Sarah J.   +3 more
core   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Adsorption of 3-chloroaniline on potato skin in aqueous solution [PDF]

, 2016
The adsorption behaviour of aromatic amine 3-chloroaniline (3-CA) from aqueous solution on fresh potato skin was investigated. A series of batch experiments were conducted under different experimental conditions of contact time, 3-chloroaniline ...
Duncan, H.J., Flowers, T.H., Mohammed, Nidhal S.   +2 more
core   +3 more sources