Results 81 to 90 of about 4,312,958 (304)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Development and evaluation of a rapid diagnostic method for Sporothrix globosa in Asia using quantitative real-time PCR

BMC Infectious Diseases
Background Sporotrichosis is a chronic granulomatous infection of the skin and subcutaneous tissue that can affect any organ through lymphatic spread. The prevalence of sporotrichosis infections is increasing and its treatment is challenging as there are
Hanqing Geng, Lele Sun, Chuan Wang, Yong Zhang, Shufen Wang, Yanru Cheng, Fangfang Bao, Hong Liu, Furen Zhang   +8 more
doaj   +1 more source

Untargeted metabolomics yields insight into extramammary Paget’s disease mechanisms

Frontiers in Oncology
BackgroundExtramammary Paget’s disease (EMPD) is a rare cutaneous malignancy, commonly affecting the external genitalia and perianal area of the elderly with unclear pathogenesis.
Long Jiang, Long Jiang, Xiaoxiang Xu, Xiaoxiang Xu, Guorong Yan, Guorong Yan, Guorong Yan, Yuhao Wu, Yuhao Wu, Yuhao Wu, Ningyuan Xi, Ningyuan Xi, Yongxian Lai, Yongxian Lai, Guolong Zhang, Guolong Zhang, Guolong Zhang, Yeqiang Liu, Yeqiang Liu   +18 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

A prospective, double‐blinded, randomized head‐to‐head clinical trial of topical adapinoid (oleyl adapalenate) versus retinol

Skin Health and Disease
Background Retinoids, such as retinol, are widely investigated and utilized in skin care products as a treatment for photoaging but their use is limited by tolerability. Adapinoid (oleyl adapalenate, OA) is a novel third generation retinoid that is a pro‐
Nhi Nguyen, Nasima Afzal, Mildred Min, Nabeel Ahmad, Laila Afzal, Waqas Burney, Cindy J. Chambers, Raja K. Sivamani   +7 more
doaj   +1 more source

Skin phosphocreatine [PDF]

Skin Research and Technology, 2007
Background/purpose: The skin has the unique ability to survive ischemia associated with skin grafts, flaps and hair transplantation procedures. Spectroscopic data later confirmed by chromatography, immunohistochemistry and molecular biology techniques identified the presence of large quantities of phosphocreatine in human skin.
openaire   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Detection of gene mutation in a case of Nagashima-type palmoplantar keratoderma

Pifu-xingbing zhenliaoxue zazhi
[Objective] To report a case of Nagashima-type palmoplantar keratoderma (NPPK), identify pathogenic gene, and assist clinical diagnosis and classification of this disease. [Methods] Clinical data of the patient were collected.
CAO Yuanyuan, YUAN Zhaojun, JIN Chuanyang, WANG Tianzi, LIAO Xiaojie, LIU Hong   +5 more
doaj   +1 more source

A Real-World, Non-interventional Indian Study Evaluating Intensive Plant-Based Butter Moisturizing Cream in Psoriasis

Dermatology and Therapy, 2019
Introduction Psoriasis is estimated to affect 0.44–2.8% of the Indian population. Moisturizers are a key adjuvant psoriasis treatment strategy, but data regarding their effectiveness, safety and compliance pattern in an Indian context are lacking. Hence,
Hemangi Rajiv Jerajani, Jayakar Thomas, Alka Gupta, Gurram Narasimha Rao Netha, Ranju Chawla, Rashid Shaikh, Ravindra Babu, Irene Williams, Prajakta Talathi, Suyog C. Mehta, Rajan Mittal, Shivani Acharya, Sujeet N. Charugulla   +12 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source