Results 71 to 80 of about 1,899,953 (267)

New changes in pregnancy and lactation labelling: Review of dermatologic drugs

International Journal of Women's Dermatology, 2019
Background: The U.S. Food and Drug Administration has published new pregnancy and lactation labelling rules that set standards on the presentation of information with regard to drug usage during pregnancy and breastfeeding, as well as the effects on ...
Yun Pei Koh, MBBS, Elizabeth A. Tian, BSc (Pharmacy), Hazel H. Oon, MD, MRCP (UK), M.Med (Int. Med), FAMS   +2 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Single-system Langerhans Cell Histiocytosis with Skin Ulcers as the Initial Presentation

Acta Dermato-Venereologica
is missing (Short communication)
Xue-min Wang, Ye-qiang Liu, Bin Li, Ming Li, Yan Peng, Wen-cheng Jiang   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Cutaneous Nontuberculous Mycobacteria Infections Following Cosmetic Procedures: A Retrospective Study

Infection and Drug Resistance
Rui Zeng,1,2,* Jingshu Xiong,1– 3,* Wei Gao,4 Jiayi Peng,1,2 Ying Shi,1– 3 Wenyue Zhang,1– 3 Haiqin Jiang,1– 3 Chaojiang Cheng,1,2 Gai Ge,5 Zhenzhen Wang,1,2 Youming Mei,1– 3 Zhiming Chen,6 Hongsheng Wang1– 3,7 1Hospital for Skin Diseases,
Zeng R, Xiong J, Gao W, Peng J, Shi Y, Zhang W, Jiang H, Cheng C, Ge G, Wang Z, Mei Y, Chen Z, Wang H   +12 more
doaj  

Sequencing of Biologic Therapy in Hidradenitis Suppurativa: A Real‐World Analysis of Treatment in Over 15,000 Patients

JEADV Clinical Practice
Background The management of moderate to severe hidradenitis suppurativa (HS) is complex with secondary failure of monoclonal antibodies frequent. Real‐world evidence regarding the treatment landscape before starting biologic therapy has been well ...
James Pham, Tara Sholji, Raaisa Islam, Kate Burrell, Cindy Kok, John W. Frew   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Prospective Comparative Study of an Oral Synbiotic and a Myoinositol-Based Herbal Supplement in Modifying Hormone Levels and the Gut Microbiome in Non-cystic Acne

Dermatology and Therapy
Introduction Acne pathogenesis is multifactorial, involving systemic factors including gut dysbiosis, hormones, and chronic inflammation. Probiotics, myoinositol, and plant-derived molecules may modulate acne by targeting these factors.
Mildred Min, Nasima Afzal, Jessica Maloh, Ajay S. Dulai, Nabeel Ahmad, David Pinzauti, Raja K. Sivamani   +6 more
doaj   +1 more source