Results 201 to 210 of about 153,077 (256)

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

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Skin cancer prevention in Australia

British Journal of Dermatology, 2009
Australia has one of the highest skin cancer incidence and mortality rates in the world. The reason for these high rates is due in part to the high ambient UV radiation levels, combined with a predominantly susceptible fair-skinned population. To address this problem, since 1980 Australians have been exposed to social marketing campaigns to raise ...
C, Sinclair, P, Foley
openaire   +2 more sources

Skin Cancer Prevention

Nursing standard (Royal College of Nursing (Great Britain) : 1987), 1997
The Health of the Nation objectives for skin cancer will only be achieved through prevention and early detection. The key Health of the Nation objective to halt the year on year increase in skin cancer by 2000 means that this ambitious target must be tackled through a multidisciplinary approach.
U. Ringborg, E. W. Breitbart, C. C. E. Meulemans, C. J. M. de Wolf   +3 more
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Skin Cancer Prevention

2010
Primary prevention Skin Cancer is one of the most preventable cancers and there is strong evidence that UV radiation is the main environmental factor. The best interventional target for primary prevention is children. Adequate photoprotection may be achieved by wearing protective clothes and by using a broad-spectrum sunscreen ...
Del Marmol, Véronique, Bataille, Véronique, Trakatelli, Myrto Georgia, Ulrich, Claas   +3 more
openaire   +2 more sources

Preventing Skin Cancer

La Revue de l'Infirmière, 2019
Sophie and Pierre are spending their summer holidays on Tenerife, one of the Canary Islands. They are interrupting this self-indulgence today to assist with a skin cancer prevention campaign organised by a local health promotion agency.
openaire   +2 more sources

Prevention of Skin Cancer

The Journal of Dermatologic Surgery and Oncology, 1988
Abstract. Our understanding of the carcinogenic process as it relates to human skin cancer is growing rapidly. As this understanding increases, so will our ability to alter the process in a positive fashion. Presently, sun exposure is known to be the major carcinogen in human skin.
openaire   +2 more sources