Results 171 to 180 of about 5,185,427 (298)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Perceptions of a Culturally Tailored Narrative Video for Skin Cancer Prevention Among Spanish-Speaking Hispanic Outdoor Workers: Exploratory Study. [PDF]

JMIR Dermatol
Perez D, Gómez V, Sedeño-Delgado D, Orellana García C, Chacon M, Gonzalez M, Dash C, Mirabal-Beltran R, Hurtado-de-Mendoza A.   +8 more
europepmc   +1 more source

Skin Cancer Prevention across the G7, Australia and New Zealand: A Review of Legislation and Guidelines. [PDF]

Curr Oncol, 2023
Conte S, Aldien AS, Jetté S, LeBeau J, Alli S, Netchiporouk E, Lagacé F, Lefrançois P, Iannattone L, Litvinov IV.   +9 more
europepmc   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Reasons for Indoor and Outdoor Tanning: Starting Points for Skin Cancer Prevention Based on a Nationwide Study. [PDF]

Curr Oncol
Diehl K, Voß L, Breitbart EW, Hübner IM, Görig T.   +4 more
europepmc   +1 more source

Determination of sunburn and skin cancer risk of outpatients in a dermatology polyclinic

, 2005
Public health experts and medical professionals continue to issue warnings to people about the dangers of ultraviolet (UV) radiation fromthe sun, tanning beds, and sun lamps. Skin cancer is more common than any other type of cancer and exposure to sun is
Sari D., Genc R.E., Turgay A.S., Can M.
core  

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Skin cancer prevention: knowledge and perceptions of a nationwide sample of youth. [PDF]

Ann Fam Med, 2022
Strome A, Chang T, Waselewski M, Lamberg O, Herbert K.   +4 more
europepmc   +1 more source

ChatGPT-Generated Advice on Sun Protection and Skin Cancer Prevention Compared to American Academy of Dermatology Guidelines: Cross-Sectional Content Analysis. [PDF]

JMIR Dermatol
Qeyam H, Al-Rusan A.
europepmc   +1 more source