Results 61 to 70 of about 5,185,427 (298)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Epigenetic Cancer Prevention Mechanisms in Skin Cancer [PDF]

The AAPS Journal, 2013
Epigenetics is an important emerging area for study of mechanisms of cancer prevention. In recent years, it has been realized that cancer prevention agents, derived from natural dietary sources, impact cancer cell survival by modulating epigenetic processes.
Kamalika, Saha, Thomas J, Hornyak, Richard L, Eckert   +2 more
openaire   +2 more sources

The seroepidemiology of human-papillomavirus in relation to non-melanoma skin cancer [PDF]

, 2009
PhDNon-melanoma skin cancer, comprising basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) is the most commonly diagnosed cancer in Caucasian populations.
Casabonne, Delphine
core   +4 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Assessment of postgraduate skin lesion education among Iowa family physicians

SAGE Open Medicine, 2017
Background: Family medicine physicians play a pivotal role in the prevention and early detection of skin cancer. Our objective was to evaluate how family physicians believe their postgraduate training in skin cancer screening and prevention has prepared ...
Nicholas J Goetsch, James D Hoehns, John E Sutherland, Matthew E Ulven, Olayinka O Shiyanbola, Monica K Rauch   +5 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention

, 2019
Tanriverdi, Ozgur/0000-0002-0598-7284; Yildiz, Aysegul/0000-0001-6356-7459WOS: 000489249900002PubMed ID: 31624720Cancer is the most common cause of death worldwide. Annually, more than ten million new cancer cases are diagnosed, and more than six million
Tanrıverdi, Özgür, Yildiz, Aysegul, Kaya, Yesim   +2 more
core   +1 more source

Risk determination and prevention of breast cancer [PDF]

, 2014
Breast cancer is an increasing public health problem. Substantial advances have been made in the treatment of breast cancer, but the introduction of methods to predict women at elevated risk and prevent the disease has been less successful.
Howell, Anthony; id_orcid, Anderson, Annie, Key, Timothy, Montserat Garcia-Closas, A. Howell (7638146), Saxton, John, M. N. Harvie (7671182), J. M. Saxton (7638221), Annie S Anderson, Saxton, John M, Robert B Clarke, Michelle N Harvie, Evans, Gareth, Key, Timothy J., M. Garcia-Closas (7638116), Garcia-Closas, Montserat, Andy J. Gescher (7671179), Key, TJ, Clarke, Robert; id_orcid, Saxton, JM, D. G. Evans (7608134), Gescher, Andy J, Stephen W Duffy, Key, Timothy J, Clarke, Robert, Harvie, Michelle N., Harvie, Michelle, Anthony Howell, Anderson, Annie S.; id_orcid, Harvie, MN, D Gareth Evans, John M Saxton, Gescher, AJ, Clarke, RB, T. J. Key (7638161), Duffy, Stephen W., Anderson, AS, Anderson, Annie S, R. B. Clarke (7638080), Howell, A, Duffy, SW, Andy J Gescher, Clarke, Robert B., Saxton, John M., Duffy, Stephen W, Evans, Gareth; id_orcid, Duffy, Stephen, S. W. Duffy (7638095), Timothy J Key, Garcia-Closas, M, A. S. Anderson (7638050), Howell, Anthony, Gescher, Andy, Evans, DG, Evans, D. Gareth, Gescher, Andy J.   +55 more
core   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Early detection of skin cancer: experience of a skin cancer prevention campaign in Piauí-Brazil - doi: 10.5020/18061230.2012.p221

Revista Brasileira em Promoção da Saúde, 2012
Objectives: To evaluate the correlation between the diagnoses of skin cancer and known risk factors through analysis of data from the National Skin Cancer Prevention Campaign held by Brazilian Society of Dermatology in the state of Piauí, Brazil, in ...
Rafael Bandeira Lages, Patrícia Barros Barbosa, Isabella Parente Almeida, Lauro Rodolpho Soares Lopes, Lauro Lourival Lopes Filho   +4 more
doaj   +1 more source