Results 51 to 60 of about 5,214,551 (300)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Incongruence between Physician, Patient, and Medical Chart Report of Skin Cancer Prevention Counseling

, 2022
Skin cancer incidence in the United States has risen rapidly in recent decades, underscoring the need for accessible and effective prevention practices.
Weinstock, Martin A., Martin A. Weinstock, Natalie H. Matthews, Matthews, Natalie H., Augustine W. Kang, Patricia Markham Risica, Kang, Augustine W., Risica, Patricia Markham   +7 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Epigenetic Cancer Prevention Mechanisms in Skin Cancer [PDF]

The AAPS Journal, 2013
Epigenetics is an important emerging area for study of mechanisms of cancer prevention. In recent years, it has been realized that cancer prevention agents, derived from natural dietary sources, impact cancer cell survival by modulating epigenetic processes.
Kamalika, Saha, Thomas J, Hornyak, Richard L, Eckert   +2 more
openaire   +2 more sources

The seroepidemiology of human-papillomavirus in relation to non-melanoma skin cancer [PDF]

, 2009
PhDNon-melanoma skin cancer, comprising basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) is the most commonly diagnosed cancer in Caucasian populations.
Casabonne, Delphine
core   +4 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Assessment of postgraduate skin lesion education among Iowa family physicians

SAGE Open Medicine, 2017
Background: Family medicine physicians play a pivotal role in the prevention and early detection of skin cancer. Our objective was to evaluate how family physicians believe their postgraduate training in skin cancer screening and prevention has prepared ...
Nicholas J Goetsch, James D Hoehns, John E Sutherland, Matthew E Ulven, Olayinka O Shiyanbola, Monica K Rauch   +5 more
doaj   +1 more source

Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention

, 2019
Tanriverdi, Ozgur/0000-0002-0598-7284; Yildiz, Aysegul/0000-0001-6356-7459WOS: 000489249900002PubMed ID: 31624720Cancer is the most common cause of death worldwide. Annually, more than ten million new cancer cases are diagnosed, and more than six million
Tanrıverdi, Özgür, Yildiz, Aysegul, Kaya, Yesim   +2 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Risk determination and prevention of breast cancer [PDF]

, 2014
Breast cancer is an increasing public health problem. Substantial advances have been made in the treatment of breast cancer, but the introduction of methods to predict women at elevated risk and prevent the disease has been less successful.
Howell, Anthony; id_orcid, Anderson, Annie, Key, Timothy, Montserat Garcia-Closas, A. Howell (7638146), Saxton, John, M. N. Harvie (7671182), J. M. Saxton (7638221), Annie S Anderson, Saxton, John M, Robert B Clarke, Michelle N Harvie, Evans, Gareth, Key, Timothy J., M. Garcia-Closas (7638116), Garcia-Closas, Montserat, Andy J. Gescher (7671179), Key, TJ, Clarke, Robert; id_orcid, Saxton, JM, D. G. Evans (7608134), Gescher, Andy J, Stephen W Duffy, Key, Timothy J, Clarke, Robert, Harvie, Michelle N., Harvie, Michelle, Anthony Howell, Anderson, Annie S.; id_orcid, Harvie, MN, D Gareth Evans, John M Saxton, Gescher, AJ, Clarke, RB, T. J. Key (7638161), Duffy, Stephen W., Anderson, AS, Anderson, Annie S, R. B. Clarke (7638080), Howell, A, Duffy, SW, Andy J Gescher, Clarke, Robert B., Saxton, John M., Duffy, Stephen W, Evans, Gareth; id_orcid, Duffy, Stephen, S. W. Duffy (7638095), Timothy J Key, Garcia-Closas, M, A. S. Anderson (7638050), Howell, Anthony, Gescher, Andy, Evans, DG, Evans, D. Gareth, Gescher, Andy J.   +55 more
core   +2 more sources