Results 71 to 80 of about 1,818,980 (296)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A US hospital budget impact analysis of a skin closure system compared with standard of care in hip and knee arthroplasty. [PDF]

, 2018
Background: Medicare\u27s mandatory bundle for hip and knee arthroplasty necessitates provider accountability for quality and cost of care to 90 days, and wound closure may be a key area of consideration.
Ferko, Nicole, Flener, Jana, Gargiulo, Jeanine, Hogan, Andrew, Hollmann, Sarah, Post, Zachary D., Sadik, Kay, Wurzelbacher, Steven   +7 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Tyrosinase Inhibitory Impact of Morus alba L. Root Bark: In Vitro and In Silico Studies [PDF]

Research Journal of Pharmacognosy
Background and objectives: The demand for skin care is a major concern, not only for women but also for men. Mulberry (Morus alba L.) is a medicinal plant widely used in traditional medicine, as well as for beauty and skin whitening.In this study, we ...
Nguyen Thi Huyen, Dang Kim Thu, Ngo Minh Tien, Dao Thi Huyen Trang, Trinh Thi Hau, Le Thi Huong, Trinh Phuong Thao, Nguyen Thu Hang, Bui Thanh Tung*   +8 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Ocena wiedzy studentów na temat zasad pielęgnacji cery = Evaluation of students' knowledge about skin care

Journal of Education, Health and Sport, 2016
Bojarczuk Katarzyna, Lewicki Marcin, Michalczak Magdalena, Smoleń Agata. Ocena wiedzy studentów na temat zasad pielęgnacji cery = Evaluation of students' knowledge about skin care. Journal of Education, Health and Sport. 2016;6(6):661-676.
Katarzyna Anna Bojarczuk, Marcin Lewicki, Magdalena Michalczak, Agata Smoleń   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Macroalgae-Derived Ingredients for Cosmetic Industry—An Update

Cosmetics, 2017
Aging is a natural and progressive declining physiological process that is influenced by multifactorial aspects and affects individuals’ health in very different ways.
Filipa B. Pimentel, Rita C. Alves, Francisca Rodrigues, M. Beatriz P. P. Oliveira   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Complex Role of IL‐13 in Bullous Pemphigoid: New Insights From a Retrospective Cohort Study

JEADV Clinical Practice
Background Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease, primarily affecting the elderly. The role of interleukin‐13 (IL‐13) in BP pathogenesis remains unclear, particularly regarding its potential as a therapeutic target.
Marwan Dawood, Zenab Ali Saleh, Ilanit Boyango, Orna Mirmovich Morvay, Salih Mishlab, Ziad Khamaysi, Emily Avitan‐Hersh   +6 more
doaj   +1 more source