Results 41 to 50 of about 31,983 (262)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Interactive Skin Display with Epidermal Stimuli Electrode

Advanced Science, 2019
In addition to the demand for stimuli‐responsive sensors that can detect various vital signals in epidermal skin, the development of electronic skin displays that quantitatively detect and visualize various epidermal stimuli such as the temperature ...
Eui Hyuk Kim, Hyowon Han, Seunggun Yu, Chanho Park, Gwangmook Kim, Beomjin Jeong, Seung Won Lee, Jong Sung Kim, Seokyeong Lee, Joohee Kim, Jang‐Ung Park, Wooyoung Shim, Cheolmin Park   +12 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Relations Between Dispositional Expressivity and Physiological Changes During Acute Positive and Negative Affect

Psychological Topics, 2007
The aim of the present study is to examine the relations between emotional expressivity measured by Berkeley Expressivity Questionnaire and physiological response in situations where positive and negative affects were induced.
Asmir Gračanin, Igor Kardum, Jasna Hudek - Knežević   +2 more
doaj  

Two-flash threshold, skin conductance and skin potential [PDF]

Psychonomic Science, 1967
The subjective threshold of fusion of paired light flashes (two-flash threshold) and tonic levels of skin conductance and skin potential were simultaneously measured in samples of drug free and medicated psychiatric patients. Significant intercorrelations were found between the two-flash threshold and a range corrected index of skin conductance and ...
openaire   +1 more source

Methodological considerations in ambulatory skin conductance monitoring [PDF]

International Journal of Psychophysiology, 2011
Little is known how much skin conductance (SC) recordings from the fingers are affected by factors such as electrode site deterioration, ambient temperature (TMP), or physical activity (ACT), or by age, sex, race, or body mass index. We recorded SC, TMP, and ACT in 48 healthy control subjects for a 24-hour period, and calculated SC level (SCL), its ...
Sigrun, Doberenz, Walton T, Roth, Eileen, Wollburg, Nina I, Maslowski, Sunyoung, Kim   +4 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Increased Skin Conductance Response in the Immediate Aftermath of Trauma Predicts PTSD Risk

Chronic Stress, 2019
Background Exposure to a traumatic event leads to posttraumatic stress disorder in 10% to 20% of exposed individuals. Predictors of risk are needed to target early interventions to those who are most vulnerable.
Rebecca Hinrichs, Sanne J. H. van Rooij, Vasiliki Michopoulos, Katharina Schultebraucks, Sterling Winters, Jessica Maples-Keller, Alex O. Rothbaum, Jennifer S. Stevens, Isaac Galatzer-Levy, Barbara O. Rothbaum, Kerry J. Ressler, Tanja Jovanovic   +11 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Electrochemical Skin Conductance in Diabetic Kidney Disease [PDF]

American Journal of Nephrology, 2015
<b><i>Background:</i></b> There is a need to identify patients with diabetic kidney disease (DKD) using noninvasive, cost-effective screening tests. Sudoscan®, a device using electrochemical skin conductance (ESC) to measure sweat gland dysfunction, is valuable for detecting peripheral neuropathy.
Barry I, Freedman, Susan Carrie, Smith, Benjamin M, Bagwell, Jianzhao, Xu, Donald W, Bowden, Jasmin, Divers   +5 more
openaire   +2 more sources