Results 51 to 60 of about 40,780 (300)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Heritability of skin conductance reactivity in children

, 2008
This study assessed the genetic covariance between various measures of phasic skin conductance activity, including response amplitude and frequency of responding.
Baker, Laura,, Raine, Adrian,, Tuvblad, Catherine,, Lozano, Dora I.,, Isen, Joshua,   +4 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Electrodermal Activity Analysis at Different Body Locations

Sensors
Electrodermal activity (EDA) reflects the variation in the electrical conductance of the skin in response to sweat secretion, constituting a non-invasive measure of the sympathetic nervous system.
Patricia Gamboa, Rui Varandas, Katrin Mrotzeck, Hugo Plácido da Silva, Cláudia Quaresma   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Abnormal electrochemical skin conductance in cystic fibrosis

, 2011
BackgroundElectrochemical skin conductance measurement is an active electrophysiologic method in which incremental low direct voltage is applied on the skin.
Hubert, Dominique, Fajac, Isabelle, Philippe Brunswick, Dusser, Daniel, Brunswick, Philippe, Daniel Dusser, Isabelle Fajac, Jean-Henri Calvet, Calvet, Jean-Henri, Dominique Hubert   +9 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Modeling Stratum Corneum Swelling for the Optimization of Electrode-Based Skin Hydration Sensors

Sensors, 2021
We present a novel computational model of the human skin designed to investigate dielectric spectroscopy electrodes for stratum corneum hydration monitoring.
Claudio Malnati, Daniel Fehr, Fabrizio Spano, Mathias Bonmarin   +3 more
doaj   +1 more source

Aggregate disposition effect and skin conductance response.

, 2013
Aggregate disposition effect and skin conductance response.
Andre Santos (287358), Sergio Da Silva (287360), Newton Da Costa Jr (287357), Emilio Takase (287359), Marco Goulart (287356)   +4 more
core   +1 more source