Results 121 to 130 of about 350,517 (216)

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Correction: Impaired NLRP3 inflammasome activaton by chitin underlies refractory chromoblastomycosis caused by Fonsecaea pedrosoi muriform cells

Frontiers in Immunology
Yao Chen, Yao Chen, Zilu Qu, Zilu Qu, Zhaolan Xie, Xiaowen Wang, Zhongsheng Tong, Zhongsheng Tong, Luoyao Yang, Luoyao Yang, Xu Zhang, Xu Zhang, Liuqing Chen, Liuqing Chen, Bilin Dong, Bilin Dong   +15 more
doaj   +1 more source

Sepsis Secondary to Crusted Scabies Following Iatrogenic Treatment for Hansen's Disease in an Indigenous Amazonian Patient: A Case Report. [PDF]

Case Rep Infect Dis
da Silva ABN, Gadelha MSM, Cei GL, do Carmo AF, Rodrigues AM.   +4 more
europepmc   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Diverging Global Patterns and Temporal Trends in Inflammatory and Infectious Skin Diseases

Clinical, Cosmetic and Investigational Dermatology
Qingrong Ni,1,* Lin Xia,2,* Xiaoying Yuan,1,* Ye Huang,1 Weijie Gu,1 Yijin Wang,1 Fan Fang,1,3 Zhiyong Wang,1 Yuanyuan Li,1 Ping Zhang,1 Hong Cai1 1Department of Dermatology, Air Force Medical Center, Fourth Military Medical ...
Ni Q, Xia L, Yuan X, Huang Y, Gu W, Wang Y, Fang F, Wang Z, Li Y, Zhang P, Cai H   +10 more
doaj  

Green Foot Discoloration Secondary to Pseudomonas aeruginosa in an Elderly Male. [PDF]

Cureus
Bhullar JK.
europepmc   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Development and Application of a Desirability of Outcome Ranking (DOOR) Endpoint for Acute Bacterial Skin and Skin Structure Infections. [PDF]

Open Forum Infect Dis
Howard-Anderson J, Hamasaki T, Ge L, Collyar D, Cosgrove SE, Doernberg SB, Geres H, Gopinath R, Holland TL, King HA, Nambiar S, Rubin D, Chambers HF, Fowler VG, Evans SR, Boucher HW.   +15 more
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Vectors Are Not Just Culture Vessels. [PDF]

Clin Infect Dis
Telford SR, Wormser GP, Dardick K, Marcos LA, Tokarz R, Hu LT, Marques AR.   +6 more
europepmc   +1 more source