Results 1 to 10 of about 25,607 (151)
Plectin in Skin Fragility Disorders [PDF]
Cells, 2021 Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold.
Dimitra Kiritsi +2 more
doaj +6 more sources
Skin fragility in a cat presenting with pituitary-dependent hyperadrenocorticism [PDF]
Journal of Feline Medicine and Surgery Open Reports, 2023 Case summary A case of skin fragility in an 8-year-old domestic shorthair cat with pituitary-dependent hyperadrenocorticism is described. The cat was referred to the Feline Centre at Langford Small Animal Hospital with a 2-month history of multiple skin ...
Lorna Hardy +3 more
doaj +3 more sources
Skin Fragility: Perspectives on Evidence-based Therapies [PDF]
Acta Dermato-Venereologica, 2020 The term skin fragility disorders describes a group of conditions in which the structural integrity of the skin is compromised and its resistance to external shear forces diminished.
Leena Bruckner-Tuderman
doaj +6 more sources
Advances in understanding the molecular basis of skin fragility [version 1; referees: 2 approved] [PDF]
F1000Research, 2018 Skin fragility refers to a large group of conditions in which the ability of the skin to provide protection against trivial mechanical trauma is diminished, resulting in the formation of blisters, erosions, wounds, or scars.
Cristina Has
doaj +6 more sources
Arrhythmogenic right ventricular cardiomyopathy in patients with biallelic JUP-associated skin fragility [PDF]
Scientific Reports, 2020 Arrhythmogenic right ventricular cardiomyopathy (ARVC), with skin manifestations, has been associated with mutations in JUP encoding plakoglobin. Genotype–phenotype correlations regarding the penetrance of cardiac involvement, and age of onset have not ...
Hassan Vahidnezhad +17 more
doaj +2 more sources
Juvenile-onset Skin Fragility with Acral Blistering: A Quiz [PDF]
Acta Dermato-Venereologicais missing (Quiz)
Kaan Yilmaz +2 more
doaj +2 more sources
Ectodermal dysplasia-skin fragility syndrome: A rare case report [PDF]
Indian Journal of Dermatology, 2015 Ectodermal dysplasia/skin fragility syndrome (ED-SFS) is a newly described autosomal recessive disorder characterized by skin fragility and blistering, palmoplantar keratoderma, abnormal hair growth, nail dystrophy, and occasionally defective sweating ...
Subhash Kashyap +2 more
doaj +2 more sources
Small-molecule therapies for genetic skin fragility. [PDF]
Mol Ther, 2014 Of the known genetic skin diseases, dystrophic epidermolysis bullosa (DEB) is a prime target for therapy development. It is a monogenic, strongly disabling disorder with high unmet medical need. Lifelong generalized skin blistering as a consequence of minor mechanical friction, chronic wounds, excessive scarring, and progressive soft-tissue fibrosis ...
Bruckner-Tuderman L.
europepmc +4 more sources
An Adamts2 Knock-In Model of Dermatosparaxis Ehlers–Danlos Syndrome Reveals Defective Collagen Maturation [PDF]
BiomedicinesBackground/Objectives: Dermatosparaxis Ehlers–Danlos syndrome (dEDS) is a rare autosomal recessive connective tissue disorder caused by biallelic pathogenic variants in ADAMTS2, which encodes the primary N-proteinase responsible for fibrillar procollagen
Taylor Petrucci-Nelson +15 more
doaj +2 more sources
The World’s Fragile Skin [PDF]
Angelaki, 2021 Some ancient philosophers compared the world to a big animal. This was vigorously opposed by modernity – the Enlightenment and the nineteenth century – , which compared it to a machine.
Jean-Luc Nancy +2 more
openaire +1 more source