Results 1 to 10 of about 24,173 (249)
Advances in understanding the molecular basis of skin fragility [PDF]
F1000Research, 2018 Skin fragility refers to a large group of conditions in which the ability of the skin to provide protection against trivial mechanical trauma is diminished, resulting in the formation of blisters, erosions, wounds, or scars. Acquired and physiological skin fragility is common; genetic disorders are rare but give insight into the molecular mechanisms ...
Cristina Has
exaly +8 more sources
Plectin in Skin Fragility Disorders. [PDF]
Cells, 2021 Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold. It functions as a mediator of keratinocyte mechanical stability in the skin, primarily through linking intermediate filaments to hemidesmosomes.
Kiritsi D, Tsakiris L, Schauer F.
europepmc +7 more sources
Skin Fragility: Perspectives on Evidence-based Therapies. [PDF]
Acta Derm Venereol, 2020 The term skin fragility disorders describes a group of conditions in which the structural integrity of the skin is compromised and its resistance to external shear forces diminished. Skin fragility can have different causes, ranging from genetic variations to inflammatory or physical phenomena.
Bruckner-Tuderman L.
europepmc +6 more sources
Skin fragility in a cat presenting with pituitary-dependent hyperadrenocorticism [PDF]
Journal of Feline Medicine and Surgery Open Reports, 2023 Case summary A case of skin fragility in an 8-year-old domestic shorthair cat with pituitary-dependent hyperadrenocorticism is described. The cat was referred to the Feline Centre at Langford Small Animal Hospital with a 2-month history of multiple skin ...
Lorna Hardy +2 more
exaly +3 more sources
Small-molecule therapies for genetic skin fragility. [PDF]
Mol Ther, 2014 Of the known genetic skin diseases, dystrophic epidermolysis bullosa (DEB) is a prime target for therapy development. It is a monogenic, strongly disabling disorder with high unmet medical need. Lifelong generalized skin blistering as a consequence of minor mechanical friction, chronic wounds, excessive scarring, and progressive soft-tissue fibrosis ...
Bruckner-Tuderman L.
europepmc +4 more sources
The World’s Fragile Skin [PDF]
Angelaki, 2021 Some ancient philosophers compared the world to a big animal. This was vigorously opposed by modernity – the Enlightenment and the nineteenth century – , which compared it to a machine.
Jean-Luc Nancy +2 more
openaire +1 more source
A Recent Advance in the Closure of Skin Wounds on Fragile Skin
Case Reports in Emergency Medicine, 2021 The delicate nature of the skin in elderly patients poses a difficult challenge to healthcare providers. Emergency departments are frequently presented with traumatic skin tears and soft tissue avulsions in this group of patients. Procedures aimed at closure of these types of wounds often result in worsening of the tears.
John Ko, Jeffrey S. Freed
openaire +3 more sources
Chemical chaperone therapy, a new strategy for genetic skin fragility disorders [PDF]
Experimental Dermatology, 2016 Jean Christopher Chamcheu +2 more
exaly +2 more sources
KLHL24: Beyond Skin Fragility [PDF]
Journal of Investigative Dermatology, 2019 KLHL24 mutations have recently been associated with epidermolysis bullosa simplex. Initial studies focused on skin fragility. However, the picture of KLHL24 mutations causing extracutaneous human disease is emerging, with dilated cardiomyopathy as a strong association. In addition, neurological disease is suspected as well.
Bolling, Maria C., Jonkman, Marcel F.
openaire +2 more sources
Skin-to-skin parental contact with fragile preterm infants
Journal of Osteopathic Medicine, 1997 Abstract Skin-to-skin contact has been implemented recently to facilitate maternal-infant bonding of preterm infants. The technique allows the removal of fragile preterm infants from an incubator to the bare chest of a parent or caretaker.
G M, Cleary +3 more
openaire +2 more sources