Results 91 to 100 of about 3,255,281 (310)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Molecular Identification of Etiological Agents in Fungal and Bacterial Skin Infections: United States, 2020–2024

Infectious Disease Reports
Background/Objectives: Cutaneous infections of fungal and bacterial origins are common. An accurate diagnosis—especially concerning pathogens that are difficult to isolate on culture—can be achieved using molecular methods (PCR) with a short turnaround ...
Aditya K. Gupta, Tong Wang, Sara A. Lincoln, Hui-Chen Foreman, Wayne L. Bakotic   +4 more
doaj   +1 more source

The Antimicrobial and Immunomodulatory Function of RNase 7 in Skin

Frontiers in Immunology, 2019
The human ribonuclease RNase 7 has been originally isolated from human skin and is a member of the human RNase A superfamily. RNase 7 is constantly released by keratinocytes and accumulates on the skin surface.
Franziska Rademacher, Sylvia Dreyer, Verena Kopfnagel, Verena Kopfnagel, Regine Gläser, Thomas Werfel, Thomas Werfel, Jürgen Harder   +7 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Early Lymphocyte Loss and Increased Granulocyte/Lymphocyte Ratio Predict Systemic Spread of Streptococcus pyogenes in a Mouse Model of Acute Skin Infection

Frontiers in Cellular and Infection Microbiology, 2018
Background: Group A streptococci may induce lymphopenia, but the value of lymphocyte loss as early biomarkers for systemic spread and severe infection has not been examined systematically.Methods: We evaluated peripheral blood cell indices as biomarkers ...
Torsten G. Loof, Aaqib Sohail, Aaqib Sohail, Aaqib Sohail, Mahmoud M. Bahgat, Aravind Tallam, Haroon Arshad, Manas K. Akmatov, Manas K. Akmatov, Marina C. Pils, Ulrike Heise, Andreas Beineke, Frank Pessler, Frank Pessler, Frank Pessler   +14 more
doaj   +1 more source

Porcine model of a complicated skin and soft tissue infection caused by Pseudomonas aeruginosa

Pseudomonas aeruginosa poses a significant threat to both immunocompetent and immunocompromised individuals, often resulting in life -threatening infections.
Polaštík Kleknerová, Dominika, Růžička, Filip, Lipový, Břetislav, Jeklová, Edita, Matýsková, Dominika, Vacek, Lukáš, Lišková, Lenka, Holoubek, Jakub   +7 more
core   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Potentiality of Melittin-Loaded Niosomal Vesicles Against Vancomycin-Intermediate Staphylococcus aureus and Staphylococcal Skin Infection

International Journal of Nanomedicine, 2021
Sirikwan Sangboonruang,1 Natthawat Semakul,2 Mohammad A Obeid,3 Marta Ruano,4 Kuntida Kitidee,5 Usanee Anukool,6,7 Kidsadagon Pringproa,8 Panuwan Chantawannakul,9 Valerie A Ferro,4 Yingmanee Tragoolpua,9 Khajornsak Tragoolpua6,7 1Biotechnology Section ...
Sangboonruang S, Semakul N, Obeid MA, Ruano M, Kitidee K, Anukool U, Pringproa K, Chantawannakul P, Ferro VA, Tragoolpua Y, Tragoolpua K   +10 more
doaj  

Skin Infections [PDF]

, 2019
Cutaneous infections are common in immunocompromised patients. Neutropenia predisposes patients to fungal, bacterial and viral infections. Antibacterial antifungal and antiviral prophylaxis have caused a significant reduction in some of these infections.
Rihana, Nancy, Sampson, Mindy
openaire   +1 more source