Results 71 to 80 of about 3,255,281 (310)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Severe bacterial skin infections

Anais Brasileiros de Dermatologia, 2020
The severe bacterial diseases discussed herein are those that present dermatological lesions as their initial manifestations, for which the dermatologist is often called upon to give an opinion or is even the first to examine the patient. This review focuses on those that evolve with skin necrosis during their natural history, that is, necrotizing ...
Sílvio Alencar Marques, Luciana Patrícia Fernandes Abbade   +1 more
openaire   +6 more sources

Proteophosophoglycans regurgitated by Leishmania-infected sand flies target the L-arginine metabolism of host macrophages to promote parasite survival [PDF]

, 2009
All natural Leishmania infections start in the skin; however, little is known of the contribution made by the sand fly vector to the earliest events in mammalian infection, especially in inflamed skin that can rapidly kill invading parasites.
Podinovskaia, M, Rogers Matthew, Matthew Rogers, Rogers, Matthew E., Choi Beak-San, Choi, BS, Maria Podinovskaia, Kropf Pascale, Rogers, M, Bates, P, Dillon, R, Ingrid Müller, Kropf, P, Müller, Ingrid, Choi, B. S., Bates Paul, Podinovskaia, M., Kropf, P., Kropf, Pascale, Podinovskaia, Maria, Beak-San Choi, Rogers, Matthew, Dillon, Rod, Rod Dillon, Muller, I, Pascale Kropf, Dillon Rod, Bates, Paul, Müller Ingrid, Podinovskaia Maria, Choi, Beak-San, Paul Bates, Müller, I.   +32 more
core   +1 more source

Recapitulating productive infection of mpox virus in human skin organoids

, 2022
Bulk-RNA sequencing data of monkeypox (mpox) virus infection in human skin organoids. The dataset includes 1h and 7 days post-infection of mpox virus in human skin organoids, and treatment with antiviral drug TPOXX for 7 days post ...
Pan, PhD Q (Erasmus University Medical Center)
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Phytochemical screening and antibacterial activity of Azadirachta Indica leaves extract on common skin infection bacteria / Mohamad Azhar Azman ... [et al.] [PDF]

, 2016
Skin infection is mainly caused by bacteria that are widely experienced by people around the world. The overuse of antibiotics has caused the development of resistant strains of bacteria.
Azman, Mohamad Azhar, Raja Sahrom, Raja Muhammad Aliff Ariffin, Nik Abdul Halim, Noor Aisyah, Jaafar Sidek, Hamidah, Md Sharudin, Muhamad Shafizul   +4 more
core  

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

ALA-PDT promotes the death and contractile capacity of hypertrophic scar fibroblasts through inhibiting the TGF-β1/Smad2/3/4 signaling pathway

Photodiagnosis and Photodynamic Therapy
Background: Hypertrophic scars, an abnormal wound-healing response to burn injuries, are characterized by massive fibroblast proliferation and excessive deposition of extracellular matrix and collagen.
Zilu Qu, Yao Chen, Kun Du, JiaXi Qiao, Liuqing Chen, Jinbo Chen, Li Wei   +6 more
doaj   +1 more source