Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity
Angewandte Chemie, EarlyView.A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu +16 more
wiley +2 more sources
HIDDEN HEALTH COSTS OF PESTICIDE USE IN ZIMBABWE'S SMALLHOLDER COTTON [PDF]
Balancing the numerous benefits that may accrue from pesticide use on cotton, farmers face health hazards. Pesticide-induced acute symptoms significantly increased the cost of illness in a survey of 280 smallholder cotton growers in two districts of ...
Maumbe, Blessing M., Swinton, Scott M.
core +1 more source
Microemulsion Gels of Tapentadol Hydrochloride: Statistical Analysis of Pharmacokinetics and Skin Irritation Studies. [PDF]
NanotheranosticsMadhavi N +3 more
europepmc +1 more source
Tailored Limonene-Based Nanosized Microemulsion: Formulation, Physicochemical Characterization and In Vivo Skin Irritation Assessment. [PDF]
Adv Pharm Bull, 2021 Mehanna MM, Abla KK, Elmaradny HA.
europepmc +1 more source
Advanced Intelligent Systems, EarlyView.This work presents a lightweight Miura‐origami soft knee exoskeleton powered by vacuum actuation and integrated with a multimodal physiological intent‐recognition system, providing real‐time assistance during sit‐to‐stand movement to reduce muscle effort and improve user comfort.
Yuchuan Jia +5 more
wiley +1 more source
Pre-validation of a novel reconstructed skin equivalent model for skin irritation and nanoparticle risk assessment. [PDF]
Nanoscale AdvSanches PL +9 more
europepmc +1 more source
The Prevalence and Clinical Features of Skin Irritation Caused by Infection Prevention Measures During COVID-19 in the Mecca Region, Saudi Arabia. [PDF]
Clin Cosmet Investig Dermatol, 2021 ZahrAllayali A +7 more
europepmc +1 more source
New approaches to treating chronic obstructive pulmonary disease with Colla corii asini
Animal Models and Experimental Medicine, EarlyView.Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang +5 more
wiley +1 more source
Sociodemographic, environmental and labor conditions related to the presence of conjunctivitis and skin irritation in a group of informal street vendors in downtown Medellin, 2015-2019. [PDF]
Rev Bras Med Trab, 2021 Garzón Duque MO +7 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li +9 more
wiley +1 more source