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European, multicentre, prospective observational phase IV clinical study to assess the impact of lebrikizumab on health-related well-being and control of skin manifestations in patients with moderate-to-severe atopic dermatitis (ADTrust): study protocol. [PDF]

BMJ Open
Augustin M, Bewley A, Brüggen MC, de Bruin-Weller MS, Ezzedine K, Ferrucci SM, Gkalpakiotis S, Herranz P, Johansson EK, Kampe T, Lapeere H, Legat FJ, Rehbinder EM, Szepietowski JC, Torres T, Vestergaard C, Werfel T, Domenech A, Massana E, Koscielny V, Narayanan S, Kasujee I, Gutermuth J.   +22 more
europepmc   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

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Skin manifestations of sarcoidosis

La Presse Médicale, 2012
The skin manifestations of sarcoidosis are classified as specific, where biopsy reveals non-caseating granulomas, and non-specific, typically erythema nodosum. The most frequent specific (granulomatous) skin lesions are maculopapules, subcutaneous nodules, scar sarcoidosis, plaques and lupus pernio.
Juan, Mañá, Joaquim, Marcoval
openaire   +2 more sources

Skin manifestations in CDG

Journal of Inherited Metabolic Disease, 2014
AbstractThe group of congenital disorders of glycosylation (CDG) has expanded tremendously since its first description in 1980, with around 70 distinct disorders described to date. A great phenotypic variability exists, ranging from multisystem disease to single organ involvement.
D, Rymen, J, Jaeken
openaire   +2 more sources

Skin manifestations of running

Journal of the American Academy of Dermatology, 2006
As the United States comes increasingly closer to being the heaviest nation on earth, many people are turning to exercise, especially running, to lose weight. Most runners, whether novice or professional, will have a skin disorder that may prompt them to seek medical attention.
Erica A, Mailler-Savage, Brian B, Adams
openaire   +2 more sources

Skin manifestations in acromegaly

Clinics in Dermatology, 2006
Cutaneous changes in acromegaly result from excess GH and IGF-1 action on skin cells and adnexae. Skin puffiness due to dermal glycosaminoglycan accumulation and edema are most prominent in the face, hands and feet. Oily skin with large pores, hypertrichosis, and excessive sweating are common features.
Anat, Ben-Shlomo, Shlomo, Melmed
openaire   +2 more sources

Skin Manifestations of Internal Malignancy

Postgraduate Medicine, 1967
Skin may be invaded by metastases from nearly any internal malignancy. The entire skin surface should be carefully inspected when an internal malignancy is suspected. Skin changes common to many diseases including malignancy are considered, as well as syndromes or entities which occur often enough with internal malignancy to warrant consideration of ...
C E, Wheeler, D C, Abele, R A, Briggaman
openaire   +2 more sources

Skin manifestations of pentazocine abuse

Journal of the American Academy of Dermatology, 1980
Seventeen patients who had cutaneous complications following pentazocine injections are presented. The mean age was 50 years; total daily pentazocine dose ranged from 60 to 2,400 mg; evidence of psychiatric illness was present in 94%, and previous drug or alcohol abuse was noted in 65%.
R F, Palestine, J L, Millns, G T, Spigel, A L, Schroeter   +3 more
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Dwarfism with skin manifestations

The Journal of Pediatrics, 1963
The syndrome of low birth weight (intrauterine) dwarfism embraces a variety of types, one of which is the Bloom dwarf in whom there is a rash following exposure to sunlight. Three dwarfs of the Bloom type are described, and evidence is presented to suggest a hereditary basis for the disorder.
openaire   +2 more sources