Results 71 to 80 of about 149 (148)

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

open access: yesAdvanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins   +3 more
wiley   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

open access: yesAdvanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu   +4 more
wiley   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

open access: yesAdvanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach   +7 more
wiley   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He   +4 more
wiley   +1 more source

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

open access: yesAdvanced Healthcare Materials, EarlyView.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold   +9 more
wiley   +1 more source

3D‐Printed Titanium Implants with Bioactive Peptide‐Polysaccharide Scaffolds for Personalized Bone Reconstruction

open access: yesAdvanced Healthcare Materials, EarlyView.
Porous 3D‐printed titanium implants are made bioactive by integration with a supramolecular peptide‐hyaluronic acid nanofibrillar scaffold, without the addition of exogenous cells or growth factors. Uniform filling of the implant architecture promotes vascularized, spatially homogeneous bone regeneration, significantly enhancing osteogenesis throughout
Noam Rattner   +8 more
wiley   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

open access: yesAdvanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre   +3 more
wiley   +1 more source

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

open access: yesAdvanced Healthcare Materials, EarlyView.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt   +7 more
wiley   +1 more source

Real‐Time 3D Ultrasound Imaging with an Ultra‐Sparse, Low Power Architecture

open access: yesAdvanced Healthcare Materials, EarlyView.
This article presents a novel, ultra‐sparse ultrasound architecture that paves the way for wearable real‐time 3D imaging. By integrating a unique convolutional array with chirped data acquisition, the system achieves high‐resolution volumetric scans at a fraction of the power and hardware complexity.
Colin Marcus   +9 more
wiley   +1 more source

Molecular Design of Highly Efficient Heavy‐Atom‐Free Near‐Infrared Cyanine Photosensitizers for Fluorescence Image‐Guided Photodynamic Therapy of Solid Tumors

open access: yesAdvanced Healthcare Materials, EarlyView.
Highly efficient heavy‐atom‐free NIR photosensitizers based on a heptamethine cyanine platform were developed for image‐guided photodynamic therapy. Both in vitro and in vivo results revealed that the R820‐3 photosensitizer with a highly twisted molecular structure exhibited potential for NIR fluorescence image‐guided photodynamic cancer therapy ...
Van‐Nghia Nguyen   +9 more
wiley   +1 more source

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