Results 81 to 90 of about 2,131,998 (371)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin

Acta Biomedica Scientifica, 2018
In cases of complex differential diagnosis of benign melanocytic neoplasms, dysplastic nevi and skin melanoma, clinical visual inspection and superficial dermatoscopy do not always allow an accurate diagnosis, which is especially important in cases of ...
A. V. Sokolova, N. P. Malishevskaya
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Basal-squamous cell carcinoma collision tumour in the facial region

Advances in Oral and Maxillofacial Surgery, 2021
Collision tumours are defined as multiple neoplasms adjacent to or combined within one area (Boyd and Rapini, 1994). To our knowledge this is the only case of a facial basal-squamous cell carcinoma (BCC-SCC) collision tumour identified in British ...
Georgia E. Hallett, Adam M. Holden, John Mitchard, Serryth D. Colbert   +3 more
doaj   +1 more source

Method of autofluorescence diagnostics of skin neoplasms in the near infrared region

, 2015
We propose a method for the diagnostics of skin neoplasms, based on the analysis of the changes in the autofluorescence spectra in the near infrared range. The autofluorescence was excited by means of the laser radiation with the wavelength 785 nm for ex
Y. Khristoforova, I. Bratchenko, D. N. Artemyev, O. Myakinin, S. Kozlov, A. Moryatov, V. Zakharov   +6 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. [PDF]

, 2015
Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients.
Martinez-Barbera, JP
core   +1 more source

Neoplasms of Anal Canal and Perianal Skin [PDF]

Clinics in Colon and Rectal Surgery, 2011
Tumors of the anus and perianal skin are rare. Their presentation can vary and often mimics common benign anal pathology, thereby delaying diagnosis and appropriate and timely treatment. The anatomy of this region is complex because it represents the progressive transition from the digestive system to the skin with many different co-existing types of ...
Léonard, Daniel, Beddy, D., Dozois, E.J.   +2 more
openaire   +3 more sources