Results 321 to 330 of about 62,571 (334)
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Formulation Strategies for Modulating Skin Permeation
2002I. INTRODUCTION Because of the barrier properties of the stratum corneum and, also, depending on the physicochemical properties of the drug, transport from simple vehicles will often be insufficient to achieve therapeutic drug concentrations at the site of action.
Robert J. Gyurik +4 more
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HPTLC method to study skin permeation of acylovir
Journal of Pharmaceutical and Biomedical Analysis, 2000A new simple, rapid and selective high performance thin layer chromatography (HPTLC) method is developed for the quantitation of acyclovir during in vitro skin permeation studies. Separation of guinea pig skin proteins and acyclovir was achieved by employing a mobile phase consisting of chloroform-methanol-ammonia (15:9:4, v/v/v) on precoated silica ...
S.S Dubhashi, Pradeep R. Vavia
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Standardization procedure for the in vitro skin permeation of anticholinergics
International Journal of Pharmaceutics, 1998The permeation of seven anticholinergics was studied in vitro on pig epidermal membranes, using static Franz diffusion cells. The donor solution consisted of isotonic phosphate-buffered saline, pH 7.4 with ethanol, propylene glycol and Azone(R). Tritium-labelled dexetimide was added as an internal standard.
I.J Bosman, R.A. de Zeeuw, K Ensing
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Reversible effects of permeation enhancers on human skin
European Journal of Pharmaceutics and Biopharmaceutics, 2007This study outlines a systematic approach for investigating a desired characteristic of chemicals used to facilitate the permeation of drugs across the skin that is, the reversibility of the permeation enhancement effect. This implies that the vital skin barrier function is restored and not permanently impaired after the application of these enhancers.
Kang, L. +5 more
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Pharmacokinetics of Drug Permeation through Human Skin
Journal of Pharmaceutical Sciences, 1978Based on sorption and permeation characteristics of scopolamine in human skin in vitro and drug elimination kinetics obtained from pharmacokinetic studies, a mathematical model was developed for estimating and optimizing the temporal pattern of scopolamine delivery from a transdermal therapeutic system through human skin in vivo.
W. Bayne, J.E. Shaw, S.K. Chandrasekaran
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Microwaves as a Skin Permeation Enhancement Method
2017Living systems are exposed to electromagnetic sources, including microwaves, from different sources such as sun, wireless communication technology, household microwave oven, etc. Microwaves are nonionizing but can affect biological systems through their thermal and non-thermal effects.
Azadeh Alinaghi, Hamid Moghimi
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Effect of liposomes and niosomes on skin permeation of enoxacin
International Journal of Pharmaceutics, 2001The skin permeation and partitioning of a fluorinated quinolone antibacterial agent, enoxacin, in liposomes and niosomes, after topical application, were elucidated in the present study. In vitro percutaneous absorption experiments were performed on nude mouse skin with Franz diffusion cells.
Ying Yue Wang +4 more
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A Personal View of Skin Permeation (1960-2013)
Skin Pharmacology and Physiology, 2013I want to thank Mike Roberts for arranging this issue of the journal and Annette Bunge and Richard Guy for reviewing this paper. This is, first, a history of my introduction to the field of skin permeability, and then an attempt to recall (with the inaccuracies that implies) the highlights of my research (1960-1975) on skin permeation, and finally a ...
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Basic Mathematical Principles in Skin Permeation
Journal of Toxicology: Cutaneous and Ocular Toxicology, 2002K.R. Brain, Adam C. Watkinson
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Skin Permeation Fundamentals and Application
Journal of Pharmaceutical Sciences, 1994openaire +2 more sources