Results 341 to 350 of about 1,692,764 (393)
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SMGA gels for the skin permeation of haloperidol
Journal of Controlled Release, 2005Small molecule gelling agent (SMGA) gels were developed using the gelator GP-1 in the solvents, namely, isostearyl alcohol (ISA) and propylene glycol (PG), to deliver haloperidol through the skin. The concentrations of the drug, haloperidol, the enhancer, farnesol and the gelator, GP-1 are 3 mg/ml, 5% (w/v) and 5% (w/v), respectively.
Kang, L. +5 more
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Skin Permeation of Urea Under Finite Dose Condition
Journal of Pharmaceutical Sciences, 2019In a previous study investigating the relationships between solute physicochemical properties and solvent effects on skin permeation of solutes under finite dose conditions, urea was found to have the highest percent dose absorbed among the model solutes studied. The objective of this study is to probe the mechanism of the observed high skin permeation
Rattikorn, Intarakumhaeng +4 more
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HPTLC method to study skin permeation of acylovir
Journal of Pharmaceutical and Biomedical Analysis, 2000A new simple, rapid and selective high performance thin layer chromatography (HPTLC) method is developed for the quantitation of acyclovir during in vitro skin permeation studies. Separation of guinea pig skin proteins and acyclovir was achieved by employing a mobile phase consisting of chloroform-methanol-ammonia (15:9:4, v/v/v) on precoated silica ...
S S, Dubhashi, P R, Vavia
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Reversible effects of permeation enhancers on human skin
European Journal of Pharmaceutics and Biopharmaceutics, 2007This study outlines a systematic approach for investigating a desired characteristic of chemicals used to facilitate the permeation of drugs across the skin that is, the reversibility of the permeation enhancement effect. This implies that the vital skin barrier function is restored and not permanently impaired after the application of these enhancers.
Kang, L. +5 more
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Enhanced in Vitro Skin Permeation of Cationic Drugs
Pharmaceutical Research, 1989The lipophilicity of cationic drugs can be increased by forming ion pairs with the carboxylate anion of fatty acids. Transport of cations across an isopropyl myristate (IPM) membrane was facilitated in the presence of oleic acid and lauric acid, providing an appropriate pH gradient existed.
P G, Green, J, Hadgraft, G, Ridout
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Basic Mathematical Principles in Skin Permeation
Journal of Toxicology: Cutaneous and Ocular Toxicology, 2002Adam C. Watkinson, Keith R. Brain
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Skin Morphology and Permeation Pathway Through the Skin
2017A thorough understanding of skin morphology is essential before discussing skin penetration/permeation by chemical compounds. As explained in many textbooks, skin is made up of the epidermis, dermis, and hypodermis (or subcutis), which is layered under the dermis, as shown in Fig. 1.1.
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Permeation of Chemicals Through the Skin
1986An overall risk/benefit analysis relative to the use of chemical protective clothing for protection from potentially harmful chemicals must ultimately consider the barrier effectiveness of the skin to the chemicals in question. For example, there may be cases in which some permeation of chemical through the clothing is tolerable if the skin itself is ...
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Skin permeation and thermodynamic features of curcumin-loaded liposomes
Journal of Materials Science: Materials in Medicine, 2020Virginia Campani +4 more
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