Results 191 to 200 of about 9,376 (233)

Expression of Cathepsins in Human Skin Photoaging

Skin Pharmacology and Physiology, 2010
Cathepsins are involved in regulatory mechanisms in human skin, but their role in photoaged skin remains unknown. This study investigates the role of cathepsin B, D, K, and G in skin photoaging in vivo and in vitro. Cathepsin-induced changes in skin as a result of chronic UV irradiation were detected by immunohistochemistry methods.
Y, Zheng, W, Lai, M, Wan, H I, Maibach
openaire   +2 more sources

[Photoaging of a skin].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2007
Photoaging is a skin aging caused by long-term exposure to the ultraviolet radiations of the sun. Ultraviolet activates activating protein-1 and generate reactive oxygen species which play a substantial role in collagen degradation. Clinically, photoaged skin appears as a coarse with deep wrinkles.
Ryszard, Galus, Łukasz, Zandecki, Marek, Antiszko, Katarzyna, Borowska, Stanisław, Zabielski   +4 more
openaire   +1 more source

The role of telomeres in skin aging/photoaging

Micron, 2004
Recent work has substantially elucidated the mechanisms of skin aging and photoaging. In particular, a central role for telomere-based signaling can be inferred. Intrinsic aging is largely controlled by progressive telomere shortening, compounded by low grade oxidative damage to telomeres and other cellular constituents, the consequence of aerobic ...
M G, Kosmadaki, B A, Gilchrest
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Treatment of Photoaged Skin with Topical Tretinoin

Skin Pharmacology, 2009
Once-daily application of tretinoin to photodamaged facial skin for 0-12 months results in substantial clinical and histologic improvement. As regards appearance, fine wrinkles become effaced, dyspigmentations fade, surface becomes smooth and develops a ‘rosy glow’. Histologically, atrophy and dysplasia of the epidermis are completely corrected.
A M, Kligman, J J, Leyden
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Ovariectomy Accelerates Photoaging of Rat Skin¶

Photochemistry and Photobiology, 2001
We have previously reported the formation of wrinkles, a decrease in skin elasticity and a loss in the linearity of dermal elastic fibers in rat hind limb skin irradiated with ultraviolet radiation in wavelength ranging 290-320 nm (UVB) at a suberythemal dose for 6 weeks.
K, Tsukahara, S, Moriwaki, A, Ohuchi, T, Fujimura, Y, Takema   +4 more
openaire   +2 more sources

Photoaging of the skin from phenotype to mechanisms

Experimental Gerontology, 2000
The skin is increasingly exposed to ambient UV-irradiation thus increasing its risk for photooxidative damage with longterm detrimental effects like photoaging, which is characterized by wrinkles, loss of skin tone, and resilience. Photoaged skin displays prominent alterations in the cellular component and the extracellular matrix of the connective ...
K, Scharffetter-Kochanek, P, Brenneisen, J, Wenk, G, Herrmann, W, Ma, L, Kuhr, C, Meewes, M, Wlaschek   +7 more
openaire   +2 more sources

A novel treatment option for photoaged skin

Journal of Cosmetic Dermatology, 2008
SummaryBackground  DNA damage as a result of ultraviolet (UV) exposure plays an important role in the progression of cutaneous aging. Both folic acid and creatine have been linked to the process of DNA protection and repair.Aims  This study aims to investigate the effects of a commercially available folic acid– and creatine‐containing formulation to ...
Anja, Knott, Urte, Koop, Heiko, Mielke, Katja, Reuschlein, Nils, Peters, Gesa-Meike, Muhr, Holger, Lenz, Ursula, Wensorra, Sören, Jaspers, Ludger, Kolbe, Thomas, Raschke, Franz, Stäb, Horst, Wenck, Stefan, Gallinat   +13 more
openaire   +2 more sources

Mechanisms of Photoaging and Chronological Skin Aging

Archives of Dermatology, 2002
Human skin, like all other organs, undergoes chronological aging. In addition, unlike other organs, skin is in direct contact with the environment and therefore undergoes aging as a consequence of environmental damage. The primary environmental factor that causes human skin aging is UV irradiation from the sun. This sun-induced skin aging (photoaging),
Gary J, Fisher, Sewon, Kang, James, Varani, Zsuzsanna, Bata-Csorgo, Yinsheng, Wan, Subhash, Datta, John J, Voorhees   +6 more
openaire   +2 more sources

Photoaging in Skin of Color

2009
Chronological (intrinsic) aging is that associated with the passage of time and a consequent decline in biological functions. This form of aging has a signature in the skin, evident clinically as fine wrinkling and/or skin laxity. Photoaging occurs concurrently with chronological aging but only on sun-exposed sites, and is induced by repeated exposure ...
Mary F. Bennett, Kevin D. Cooper
openaire   +1 more source

Aging and Photoaging of the Skin

2010
Skin is the largest organ of the human body. Skin is the first barrier against infection, and protects the internal organs from temperature and water loss, and from physical injuries. Skin also transmits sensory information (pressure, temperature, pain), and skin appendages produce hair, sweat, and oils (sebum).
Laure Rittié, Gary J. Fisher, John J. Voorhees   +2 more
openaire   +1 more source