Results 31 to 40 of about 144,623 (220)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis

Scientific Reports
Sweat is an essential protection system for the body, but its failure can result in pathologic conditions, including several skin diseases, such as palmoplantar pustulosis (PPP).
Kazuki Yatsuzuka, Ryosuke Kawakami, Yosuke Niko, Teruko Tsuda, Kenji Kameda, Nobushige Kohri, Satoshi Yoshida, Ken Shiraishi, Jun Muto, Hideki Mori, Yasuhiro Fujisawa, Takeshi Imamura, Masamoto Murakami   +12 more
doaj   +1 more source

A 3D-Printed Piezoelectric Microdevice for Human Energy Harvesting for Wearable Biosensors

Micromachines
The human body is a source of multiple types of energy, such as mechanical, thermal and biochemical, which can be scavenged through appropriate technological means.
Ihor Sobianin, Sotiria D. Psoma, Antonios Tourlidakis   +2 more
doaj   +1 more source

Psychophysiological correlates of peritraumatic dissociative responses in survivors of life-threatening cardiac events [PDF]

, 2002
The psychophysiological startle response pattern associated with peritraumatic dissociation (DISS) was studied in 103 survivors of a life-threatening cardiac event (mean age 61.0 years, SD 13.95).
Deisenhofer, I., Erazo, N., Hofmann, B., Ladwig, K. H., Marten-Mittag, B., Schapperer, J., Schmitt, C., Weyerbrock, S.   +7 more
core   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Multiscale modelling of fluid and solute transport in soft tissues and microvessels [PDF]

, 2010
This study focuses on the movement of particles and extracellular fluid in soft tissues and microvessels. It analyzes modeling applications in biological and physiological fluids at a range of different length scales: from between a few tens to several ...
Lu, Yiling, Wang, Wen
core   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Sporting embodiment: sports studies and the (continuing) promise of phenomenology [PDF]

, 2009
Whilst in recent years sports studies have addressed the calls ‘to bring the body back in’ to theorisations of sport and physical activity, the ‘promise of phenomenology’ remains largely under-realised with regard to sporting embodiment.
Ahmed S., Alcoff L., Allen‐Collinson J., Allen‐Collinson J., Arnold P.J., Bain L.L., Bartky S., Butler J., Colaizzi P.F., Colaizzi P.F., Connell R.W., Creswell J.W., Crossley N., Dale G.A., de Beauvoir S., De Castro A., Denison J., Dreyfus H.L., Ehrich L.C., Ellis C., Embree L., Engel L., Garfinkel H., Garfinkel H., Giorgi A., Grosz E.A., Gruppetta M., Hemphill D., Hopper T.F., Hughson J., Husserl E., Jacquelyn Allen‐Collinson, Kerry D.S., Kvale S., Maso I., McCall R., Merleau‐Ponty M., Merleau‐Ponty M., Merleau‐Ponty M., Moustakas C., Nicholls A., Parker I., Schutz A., Shildrick M., Smith J.A., Smith J.A., Sparkes A.C., Sparkes A.C., Spurling L., Todres L., Tyler I., Van den Berg J.H., van Manen M., Weiss G., Willig C., Willig C., Wrathall M.A., Young I.M.   +57 more
core   +3 more sources

Olfaction scaffolds the developing human from neonate to adolescent and beyond [PDF]

, 2020
The impact of the olfactory sense is regularly apparent across development. The foetus is bathed in amniotic fluid that conveys the mother’s chemical ecology.
Durand, Karine, Loos, Hélène, Saxton, Tamsin, Schaal, Benoist, Soussignan, Robert   +4 more
core   +3 more sources