Results 131 to 140 of about 16,012,863 (396)

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang   +16 more
wiley   +1 more source

Experimental Observations of Aerodynamic and Heating Test on Insulating Heat Shields [PDF]

open access: yes
Several different types of insulating heat shields have been subjected to aerodynamic tests and radiant-heating tests in order to obtain a better insight into the problems involved when the primary structure of m aerodynamically heated vehicle is ...
Anderson, Melvin S., Stroud, C. W.
core   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao   +5 more
wiley   +1 more source

Research on the elastic stability of large shells [PDF]

open access: yes
Tests were conducted to determine the elastic stability of large shell structures. The configuration of the shells and the instrumentation used in the measurements are described. The testing procedures are explained.
Horton, W. H.
core   +1 more source

Characteristics of Cerebral Palsy in the Midwestern US

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim   +6 more
wiley   +1 more source

Airfoil large eddy breakup devices for turbulent drag reduction [PDF]

open access: yes
It was determined from the present LaRC experiments that tandem, airfoil-shaped large eddy breakup (LEBU) devices can reduce local skin friction as much as 30 percent with a recovery region extending more than 100 boundary layer thicknesses downstream ...
Anders, J. B.
core   +1 more source

A Multi‐Center Retrospective Cohort Study of Neurosarcoidosis Myelitis: Current Observations and Future Directions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The optimal treatment for neurosarcoidosis myelitis is uncertain. We characterize incident neurosarcoidosis myelitis and assess treatment response by MRI and clinical scales. Methods Incident probable or definite neurosarcoidosis myelitis in adults was retrospectively identified from 13 academic medical centers.
Giovanna S. Manzano   +39 more
wiley   +1 more source

Anaphylaxis due to midazolam administered before induction of general anesthesia: a case report

open access: yesJA Clinical Reports
Background Anaphylaxis is an immediate allergic reaction. However, in some cases, there is a delay between the administration of the causative agent and the onset of anaphylaxis.
Ryosuke Funabiki   +5 more
doaj   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam   +6 more
wiley   +1 more source

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