Results 101 to 110 of about 1,432,523 (306)

Trial protocol for SiroSkin: a randomised double-blind placebo-controlled trial of topical sirolimus in chemoprevention of facial squamous cell carcinomas in solid organ transplant recipients

Trials
Background Keratinocyte carcinomas such as basal cell carcinomas and squamous cell carcinomas are a major burden affecting morbidity and mortality in solid organ transplant recipients (SOTRs).
Lea Dousset, Daniel C. Chambers, Angela Webster, Nicole Isbel, Scott Campbell, Carla Duarte, Louisa Collins, Diona Damian, Anne Tseng, Emma Karlsen, Olga Victoria Ilinsky, Susan Brown, Helmut Schaider, H. Peter Soyer, Daniel Ariza Ospino, Sam Hogarth, Alvin H. Chong, Victoria Mar, Scott McKenzie, Douglas Gin, Pablo Fernandez-Penas, Johannes S. Kern, Katja Loewe, Edwige Roy, Alan Herschtal, Kiarash Khosrotehrani   +25 more
doaj   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Full-thickness skin grafts in nasal reconstruction: A retrospective study

JAAD International, 2023
Joyce Chen, MD, Collin M. Costello, MD, Carolyn Mead-Harvey, MS, Katie L. Kunze, MA, PhD, Juan-Carlos Martinez, MD, Shari A. Ochoa, MD   +5 more
doaj   +1 more source

Liposomal bupivacaine for the management of postsurgical donor site pain in patients with burn injuries: a case series from two institutions

Clinical Case Reports, 2018
Key Clinical Message Donor site pain associated with skin graft procedures is frequently intense and difficult to treat. Liposomal bupivacaine, a prolonged‐release local anesthetic indicated for single‐dose administration to produce postsurgical ...
Sharmila Dissanaike, Jayne McCauley, Carlo Alphonso   +2 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

The results of reverse digital artery island flap for fingertip injuries

Acta Orthopaedica et Traumatologica Turcica, 2021
Objectives: To evaluate long-term results of reconstruction with reverse digital artery island flap in patients with fingertip injuries.\nMethods: The study included 10 patients (15 digits) who completed follow-up examinations after repair of soft tissue
Emre Orhun, Kahraman Ozturk, Ersin Nuzumlali, Selma Polatkan, Oguz Polatkan   +4 more
doaj  

Liver Transplantation With Livers From Octogenarians and a Nonagenarian

, 2015
Introduction. A shortage of deceased donors has compelled the use of extended-criteria donor organs in liver transplantation.
ÜNAL, BÜLENT, YILMAZ, SEZAİ, Onur, Asım, Soyer, V., Sarıcı, Kemal Barış, Onur, A., Yağcı, Mehmet Ali, DİRİCAN, ABUZER, Yılmaz, Sezai, SARICI, KEMAL BARIŞ, Yagci, M. A., Koc, SÜLEYMAN, Soyer, Vural, Koc, S., Dirican, A., Sarici, B., Unal, B.   +16 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Histological examination of skin grafts at day 6 after transplantation.

, 2016
Skin graft specimens were obtained from a native donor graft (a), a syngeneic transplant recipient mouse (Syngeneic Tx, b), and allotransplanted mice with the first transplantation (1st Tx, c) and second transplantation (2nd Tx, d) on day 6.
Hideki Ishida (52835), Nobuyuki Fukuzawa (3121950), Hiroshi Harada (397913), Takeshi Maehana (3121956), Kazunari Tanabe (52836), Naoya Masumori (3121953), Toshiaki Tanaka (308227), Hiroshi Kitamura (269785)   +7 more
core   +1 more source

GSH Attenuates Organ Injury and Improves Function after Transplantation of Fatty Livers [PDF]

, 2010
Ischemia-reperfusion injury (IRI) is increased after transplantation of steatotic livers. Since those livers are increasingly used for transplantation, protective strategies must be developed. Reactive oxygen species (ROS) play a key role in hepatic IRI.
Jauch, Karl-Walter, S. Pratschke, U. Grützner, Gruetzner, U., Angele, M. K., F. Loehe, M. Bilzer, M.K. Angele, Tufman, A., Löhe, F., Schauer, R. J., Bilzer, M., Pratschke, S., A. Tufman, K.-W. Jauch, R.J. Schauer   +15 more
core   +1 more source