Results 161 to 170 of about 155,274 (309)

Synovial Fluid‐derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP‐1 Signaling Pathway

Advanced Science, EarlyView.
Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen, Qingwei Zeng, Tangchang Xu, Xinyue Qi, Kaiyi Li, Jing Wei, Liang Hao   +6 more
wiley   +1 more source

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

Advanced Science, EarlyView.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun, Long Zhao, Zhen Shi, Jingting Wang, Shang Yang, Xia Qi, Hengrui Zhang, Ting Wang, Weiyun Shi   +8 more
wiley   +1 more source

Experimental study of skin-derived corneal endothelial cell-like cells for long-term monkey corneal endothelial transplantation

, 2018
Xinyi Wu
openalex   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Clinical Findings, Treatments and Outcomes of Transplant Recipients with Metastatic Skin Cancer

, 2017
Muneeb Ilyas, Amit Sharma, R Chockalingam, C Downing, S Tyring, C Ulrich, J Kanitakis, E Stockfleth, S Euvrard, S Euvrard, J Kanitakis, A Claudy, N Eisemann, J Brewer, M Athar, S Walsh, L Kopelovich, C Elmets, C Ponticelli, D Cucchiari, P Bencini, D Ducloux, A Grulich, M Van Leeuwen, M Falster, C Vajdic, M Dimon, C Clarke, H Robbins, W Barrett, M First, B Aron, I Penn, B Krynitz, B Rozell, J Lyth, K Smedby, B Lindelof, C Otley, M Pittelkow, A Lloyd, G Klintmalm, H Qin, A Menter, K Brantsch, B Cherpelis, C Marcusen, P Lang, S Farasat, M Brunner, M Veness, S Ch'ng, M Elliott, J Clark, S Song, N Brougham, E Dennett, R Cameron, S Tan, B Hoersch, U Leiter, C Garbe, J Martinez, C Ong, A Keogh, S Kossard, P Macdonald, P Spratt, G Garrett, S Lowenstein, J Singer, S He, S Arron, C Harwood, S Rashtak, Z Jiyad, C Olsen, M Burke, N Isbel, A Green, P O'donovan, C Perrett, N Sugie, N Fujii, K Danno, J Dantal, R Marcen, M Glover, J Deeks, M Raftery, J Cunningham, I Leigh, C Otley, S Maragh, E Epstein, N Epstein, K Bragg, G Linden, J Alberu, M Alter   +99 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Study finds heart transplant patients may be at risk for serious skin cancers [PDF]

, 2011
Carrie Printz
openalex   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles

Advanced Science, EarlyView.
A schematic diagram of the mechanism where small extracellular vesicles mediate the enhancement of heterotopic wound healing by radial extracorporeal shockwave stimulation at a proximal tibial osteotomy site. ABSTRACT Wound healing represents a complex biological process necessitating innovative therapeutic approaches, particularly for chronic wounds ...
Xiaoping Xie, Songqi Bi, Bang Su, Rongqi Zhou, Xudong Li, Zhixing Yan, Xiaoyang Zhou, Fanxu Wang, Tiecheng Yu   +8 more
wiley   +1 more source

Skin cancer surveillance in renal transplant recipients: questionnaire survey of current UK practice [PDF]

, 2001
Paul Harden, Sarah M. Reece, Anthony A. Fryer, Andrew G. Smith, Helen Ramsay   +4 more
openalex   +1 more source