Results 31 to 40 of about 22,140 (244)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
B. F. Skinner: teórico da ciência e teórico da moral?
Arquivos Brasileiros de Psicologia, 2014 Would Skinner's moral theory be dependent on his scientific theory to the point of becoming meaningless without it? The mere suggestion of such hypothesis brings the problem of naturalistic fallacy, that is, the problem of deriving statements of ''ought''
Diego Zilio, Kester Carrara
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
B. F. Skinner: teórico da ciência e teórico da moral?
Arquivos Brasileiros de Psicologia, 2009 Would Skinners moral theory be dependent on his scientific theory to the point of becoming meaningless without it? The mere suggestion of such hypothesis brings the problem of naturalistic fallacy, that is, the problem of deriving statements of "ought ...
Diego Zilio, Kester Carrara
doaj
B.F. SKINNER AND THE GRAND INQUISITOR
Zygon, 1995 . B.F. Skinner allures us with the possibilities of turning the stones of materialistic rewards into the bread of human values. He tempts us by assuring success in achieving our goals through behavioral science, if only we give up our autonomy.
doaj +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Interação em Psicologia, 2017 This paper is a reflection on the idea according to which there is a kind of selection dedicated to cultural practices. I will argue that this proposal was based upon a metaphorical extension of natural selection to the cultural dimension.
Diego Zilio
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source