Results 101 to 110 of about 8,084 (292)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Skinny

, 2019
Skinny’s costumes never fit properly because I wanted to show how his weight fluctuated throughout the show. In this specific scene with the Poet, she is wearing a snug fitting jumper and Skinny is swimming in his clothes because they are too big on him ...
Celestine, Akeem
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Automatic boomerang attacks search on Rijndael

Journal of Mathematical Cryptology
Boomerang attacks were introduced in 1999 by Wagner (The boomerang attack. In: Knudsen LR, editor. FSE’99. vol. 1636 of LNCS. Heidelberg: Springer; 1999. p.
Rouquette Loïc, Minier Marine, Solnon Christine   +2 more
doaj   +1 more source

Mix-Basis Geometric Approach to Boomerang Distinguishers

IACR Transactions on Symmetric Cryptology
Differential cryptanalysis relies on assumptions like Markov ciphers and hypothesis of stochastic equivalence. The probability of a differential characteristic estimated by classical methods is the key-averaged probability under the two assumptions ...
Chengcheng Chang, Hosein Hadipour, Kai Hu, Muzhou Li, Meiqin Wang   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Trail-Estimator: An Automated Verifier for Differential Trails in Block Ciphers

IACR Transactions on Symmetric Cryptology
Differential cryptanalysis is a powerful technique for attacking block ciphers, wherein the Markov cipher assumption and stochastic hypothesis are commonly employed to simplify the search and probability estimation of differential trails. However, these
Thomas Peyrin, Quan Quan Tan, Hongyi Zhang, Chunning Zhou   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Skinny necktie

, 1955
Man's skinny necktie of vertical gray and black striped silk. Square ends. Tipped in buff silk in brown "Created in Italy for / Neiman-Marcus" print; interlined.
Neiman-Marcus
core