Results 71 to 80 of about 107,602 (291)

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

open access: yesAdvanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang   +13 more
wiley   +1 more source

Effect of binocular disparity on learning anatomy with stereoscopic augmented reality visualization: A double center randomized controlled trial

open access: yesAnatomical Sciences Education, Volume 16, Issue 1, Page 87-98, January/February 2023., 2023
Abstract Binocular disparity provides one of the important depth cues within stereoscopic three‐dimensional (3D) visualization technology. However, there is limited research on its effect on learning within a 3D augmented reality (AR) environment. This study evaluated the effect of binocular disparity on the acquisition of anatomical knowledge and ...
Katerina Bogomolova   +6 more
wiley   +1 more source

An evaluation of a teaching package constructed using a Web‐based lecture recorder [PDF]

open access: yes, 1997
This paper describes an evaluation of a teaching package used to replace lectures in two closely related university courses on Discrete Mathematics. The package was developed using Audiograph, a Web‐based lecture recorder developed at the University of ...
Segal, Judith
core   +2 more sources

Trustworthy Inverse Molecular Design via Alignment with Molecular Dynamics

open access: yesAdvanced Science, EarlyView.
Data‐driven inverse molecular design (IMD) is a promising approach to discovering new molecules with desired properties. Despite the remarkable progress, existing IMD methods lag behind in terms of trustworthiness, as indicated by their misalignment with the ground‐truth function that models the molecular dynamics.
Kevin Tirta Wijaya   +3 more
wiley   +1 more source

User Equilibrium Route Assignment for Microscopic Pedestrian Simulation [PDF]

open access: yes, 2014
For the simulation of pedestrians a method is introduced to find routing alternatives from any origin position to a given destination area in a given geometry composed of walking areas and obstacles. The method includes a parameter which sets a threshold
Hofsäß, Ingmar   +2 more
core   +1 more source

A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility

open access: yesAdvanced Science, EarlyView.
This study identifies SR30, a splicing factor, as a negative regulator of tomato immunity. During Phytophthora infestans infection, the elevated SR30 forms nuclear condensates to suppress the alternative splicing (AS) of defense‐related genes in a phase separation manner.
Dong Yan   +11 more
wiley   +1 more source

Thermal Control of Vortex Motion in Nanoscale Superconductors

open access: yesAdvanced Electronic Materials, EarlyView.
Vortices in superconducting film can be thermally steered by a local heating from a tip. The work shows that the vortex is attracted by the hot spot by a force that emulates an electric field resulting in a fictious Lorentz‐force on the vortex. Abstract Thermally induced motion of vortices in nanoscale superconductors (SCs) is investigated.
Björn Niedzielski, Jamal Berakdar
wiley   +1 more source

Catalytic Approaches for CO2 Conversion to Value‐Added Products: An Overview of Life Cycle Assessment Studies

open access: yesAdvanced Energy and Sustainability Research, EarlyView.
The catalytic conversion of CO2 into value‐added products provides an emerging strategy for reducing carbon emissions and improving environmental performance. This review compares different Life Cycle Assessment studies to evaluate the environmental impacts of CO2 conversion, focusing on the main challenges, technical limitations, and potential ...
Anastasia Pappa   +3 more
wiley   +1 more source

The Effect of Web Usability on Users’ Web Experience [PDF]

open access: yes, 2012
The ease with which a website visitor can find what they need is positively correlated with visitor satisfaction(Institute for Dynamic Educational Advancement, 2008).
Herring, Molly
core   +1 more source

Exploring consumption profiles, consumer experience and quality claims of Canary Islands' cider (Spain): A multidimensional analysis

open access: yesAgribusiness, EarlyView.
Abstract The exponential expansion of the global cider market positions it as a viable alternative to traditional choices such as wine and beer. Nevertheless, there exists a paucity of research examining the various factors influencing consumer interest in cider.
Eva Parga Dans   +3 more
wiley   +1 more source

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