Results 121 to 130 of about 1,733,506 (289)

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta, Carolina Gorodetsky, Todd M. Herrington, Angela L. Hewitt, Daniel E. Lumsden, Jennifer O'Malley, Terence Sanger   +6 more
wiley   +1 more source

Directional Deep Brain Stimulation for Parkinson's Disease: Results of an International Crossover Study With Randomized, Double‐Blind Primary Endpoint

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Published reports on directional deep brain stimulation (DBS) have been limited to small, single‐center investigations. Therapeutic window (TW) is used to describe the range of stimulation amplitudes achieving symptom relief without side effects.
Alfons Schnitzler, Pablo Mir, Matthew A. Brodsky, Leonard Verhagen, Sergiu Groppa, Ramiro Alvarez, Andrew Evans, Marta Blazquez, Sean Nagel, Julie G. Pilitsis, Monika Pötter‐Nerger, Winona Tse, Leonardo Almeida, Nestor Tomycz, Joohi Jimenez‐Shahed, Witold Libionka, Fatima Carrillo, Christian J. Hartmann, Stefan Jun Groiss, Martin Glaser, Florence Defresne, Edward Karst, Binith Cheeran, Jan Vesper, for the PROGRESS Study Investigators   +24 more
wiley   +1 more source

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Neuroprotection, EarlyView.
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Lucia Fadon‐Padilla, Chengyan Chu, Lorissa McDougall, Yajie Liang, Chinmoy Sarkar, Marta Lipinski, Tim Magnus, Miroslaw Janowski, Piotr Walczak   +8 more
wiley   +1 more source

Application of Photogrammetry and Mesh Comparison in the Study of Human Cranial Morphology

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Photogrammetric methods for generating three‐dimensional (3D) models are becoming increasingly widespread in the fields of archaeology and biological anthropology. In particular, the study of the variability of skull morphology (generated by the ancestry of the individual or by the application of certain cultural practices) using 3D models is ...
Carlos Cancio Moreno, Javier Lescure, Antonio González‐Martín   +2 more
wiley   +1 more source

Exploring the causes and impact of pediatric complicated mild traumatic brain injuries

PM&R, EarlyView.
Abstract Background Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children, with mild TBI (mTBI) accounting for approximately 80% of cases. Complicated mTBI (c‐mTBI) is characterized by radiographic evidence of intracranial abnormalities and/or skull fractures.
Andrew D. Kramer, Arianna B. Lanpher, Matthew Mervis, Madison Koval, Zachary Jager, Masaru Teramoto, Michael M. Green   +6 more
wiley   +1 more source

Outcome of surgically treated non-missile traumatic depressed skull fracture

Nigerian Postgraduate Medical Journal, 2014
Aims and objective: To determine the functional outcome and infection rate in patients who were surgically treated for non-missile traumatic depressed skull fractures.
MON Nnadi, O B Bankole, S O Arigbabu
doaj  

Early middle meningeal artery embolization for small acute epidural hematomas: a clinical study from a single center

Frontiers in Neurology
ObjectiveSmall acute epidural hematomas (EDHs) are generally managed conservatively; however, in certain instances, they may necessitate surgical evacuation owing to delayed hematoma expansion.
Wei Wang, Xiaosheng Yang, Zhaoliang Sun, Weijie Zhong, Yingfan Xiong, Yang Wang, Zhixin Duan, Shenghua Chu, Xiufeng Jiang, Yi Li   +9 more
doaj   +1 more source

A case of multipl cranial nerve involvement caused by skull base and orbital wall fractures Çoklu Kraniyal Sinir Tutulumu Ile Seyreden Kafa Tabani ve Orbita Duvar Fraktürlü Bir Olgu

, 2013
Post-traumatic skull base fractures can cause cranial nerve paralysis. Mortality and morbidity rates are high in skull base fractures. Treatment modalities should be determined by a multidisciplinary evaluation.
Coşkun, Mesut, Ilhan, Özgür, Parlakfikirer, Nihan, Tuzcu, Esra Ayhan, Ilhan, Nilüfer   +4 more
core   +1 more source

Causes, treatment and outcome of external ear canal tears and avulsions in cats and dogs: 24 cases (2008‒2024)

Veterinary Record, EarlyView.
Abstract Background This study aimed to evaluate the causes, treatment options and associated complications of ear canal tears and avulsions in dogs and cats. Methods This retrospective clinical study includes 14 cats and 10 dogs diagnosed with external ear canal tears and avulsions using otoscopy and/or computed tomography.
Eva M. Billau, Cetina Thiel
wiley   +1 more source