SLC34A2 Targets in Calcium/Phosphorus Homeostasis of Mammary Gland and Involvement in Development of Clinical Mastitis in Dairy Cows [PDF]
AnimalsThe type II Na/Pi co-transporter (NaPi2b), encoded by the solute carrier (SLC) transporter 34A2 (SLC34A2), is responsible for calcium (Ca) and phosphorus (P) homeostasis. Unbalanced Ca/P metabolism induces mastitis in dairy cows.
Xueying Wang +6 more
doaj +6 more sources
New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review [PDF]
Orphanet Journal of Rare Diseases, 2023 Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive lung disease caused by variants in the SLC34A2 gene encoding the sodium-dependent phosphate transport protein 2B, NaPi-2b.
Åsa Lina M. Jönsson +4 more
doaj +6 more sources
Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases [PDF]
Biomolecules, 2021 The main goal of this study is to consider SLC34A2 as a potential prognostic marker of oncological diseases using the mutational, expression, and survival data of cancer studies which are publicly available online.
Ramilia Vlasenkova +4 more
doaj +6 more sources
Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis [PDF]
Human Genomics, 2022 Background Variants in SLC34A2 encoding the sodium-dependent phosphate transport protein 2b (NaPi-IIb) cause the rare lung disease pulmonary alveolar microlithiasis (PAM).
Åsa Lina M. Jönsson +8 more
doaj +9 more sources
SLC34A2 promotes cell proliferation by activating STX17‐mediated autophagy in esophageal squamous cell carcinoma [PDF]
Thoracic CancerBackground Solute carrier family 34 member 2 (SLC34A2) has been implicated in the development of various malignancies. However, the clinical significance and underlying molecular mechanisms of SLC34A2 in esophageal squamous cell carcinoma (ESCC) remain ...
Yi Xu +6 more
doaj +5 more sources
Increased Slc34a2 expression and paracellular phosphate permeability contribute to high intestinal phosphate absorption in young mice [PDF]
Acta Physiologica, 2023 Phosphorus is a critical constituent of bone as a component of hydroxyapatite. Bone mineral content accrues rapidly early in life necessitating a positive phosphorus balance, which could be established by a combination of increased renal reabsorption and
Tate MacDonald +5 more
semanticscholar +5 more sources
Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality [PDF]
Scientific Reports, 2021 Absorption of dietary phosphate (Pi) across intestinal epithelia is a regulated process mediated by transcellular and paracellular pathways. Although hyperphosphatemia is a risk factor for the development of cardiovascular disease, the amount of ingested
Eva Maria Pastor-Arroyo +6 more
doaj +5 more sources
Analytical Cellular Pathology, 2021 Background. Papillary thyroid carcinoma (PTC) usually has an indolent clinical course, yet a subset of patients might show an aggressive course. Thus, better stratification of at-risk patients is mandatory for proper management.
Sarah Adel Hakim +3 more
doaj +3 more sources
#2685 SLC34A2 EXACERBATES TUBULAR INTERSTITIAL FIBROSIS VIA INDUCTION OF APOPTOSIS AND CELL CYCLE ARREST IN S PHASE [PDF]
Nephrology, Dialysis and Transplantation, 2023 Chronic kidney disease (CKD) is an urgent public health issue in the world. However, effective treatments for intervention of CKD remain undefined.
Liang-Shuan Hu +8 more
openalex +2 more sources
Transient DUX4 expression induces blastomere-like expression program that is marked by SLC34A2 [PDF]
bioRxiv, 2021 DUX4 has recently been recognized as a key regulator in human embryonic genome activation (EGA). The exact role of DUX4 in human embryo is still elusive, partly due to the cytotoxicity of persistent DUX4 expression in cellular models. We report here that
Masahito Yoshihara +14 more
openalex +2 more sources