Human-specific activation of the DUX4-SLC34A2 axis by herpesviruses suppresses antiviral innate immunity [PDF]
mBioViral pathogens employ diverse strategies to antagonize host antiviral innate immune defenses. However, the human-specific nature of viral immune evasion mechanisms remains poorly understood.
Ming Gao +10 more
doaj +3 more sources
Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases [PDF]
Biomolecules, 2021 The main goal of this study is to consider SLC34A2 as a potential prognostic marker of oncological diseases using the mutational, expression, and survival data of cancer studies which are publicly available online.
Ramilia Vlasenkova +4 more
doaj +2 more sources
Evaluation of the Prognostic Value of Solute Carrier Family 34 Member 2 “SLC34A2” in Papillary Thyroid Carcinoma: An Immunohistochemical Study [PDF]
Analytical Cellular Pathology, 2021 Background. Papillary thyroid carcinoma (PTC) usually has an indolent clinical course, yet a subset of patients might show an aggressive course. Thus, better stratification of at-risk patients is mandatory for proper management.
Sarah Adel Hakim +3 more
doaj +2 more sources
Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality [PDF]
Scientific Reports, 2021 Absorption of dietary phosphate (Pi) across intestinal epithelia is a regulated process mediated by transcellular and paracellular pathways. Although hyperphosphatemia is a risk factor for the development of cardiovascular disease, the amount of ingested
Eva Maria Pastor-Arroyo +6 more
doaj +2 more sources
Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis [PDF]
Human Genomics, 2022 Background Variants in SLC34A2 encoding the sodium-dependent phosphate transport protein 2b (NaPi-IIb) cause the rare lung disease pulmonary alveolar microlithiasis (PAM).
Åsa Lina M. Jönsson +8 more
doaj +4 more sources
New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review [PDF]
Orphanet Journal of Rare Diseases, 2023 Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive lung disease caused by variants in the SLC34A2 gene encoding the sodium-dependent phosphate transport protein 2B, NaPi-2b.
Åsa Lina M. Jönsson +4 more
doaj +2 more sources
Increased Slc34a2 expression and paracellular phosphate permeability contribute to high intestinal phosphate absorption in young mice [PDF]
, 2023 Aim: Phosphorus is a critical constituent of bone as a component of hydroxyapatite. Bone mineral content accrues rapidly early in life necessitating a positive phosphorus balance, which could be established by a combination of increased renal ...
Tate MacDonald +5 more
openalex +4 more sources
Differences in genetic characteristics between Chinese and non-Chinese patients with pulmonary alveolar microlithiasis—case series and a systematic review [PDF]
Therapeutic Advances in Respiratory DiseaseBackground: Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive disorder caused by SLC34A2 variants, characterized by diffuse alveolar calcium phosphate deposits.
Mengyao Guo +7 more
doaj +2 more sources
SLC34A2 promotes cell proliferation by activating STX17‐mediated autophagy in esophageal squamous cell carcinoma [PDF]
Thoracic CancerBackground Solute carrier family 34 member 2 (SLC34A2) has been implicated in the development of various malignancies. However, the clinical significance and underlying molecular mechanisms of SLC34A2 in esophageal squamous cell carcinoma (ESCC) remain ...
Yi Xu +6 more
doaj +2 more sources
The effects and mechanisms of SLC34A2 on maintaining stem cell-like phenotypes in CD147 breast cancer stem cells [PDF]
Tumor Biology, 2017 The cancer stem cell (CSC) hypothesis has gained significant recognition in describing tumorigenesis. Identification of the factors critical to development of breast cancer stem cells (BCSCs) may provide insight into the improvement of effective ...
Yonggang Lv +14 more
doaj +2 more sources