Results 11 to 20 of about 3,033 (181)

The influence of ROS1 fusion partners and resistance mechanisms in ROS1-TKI-treated non-small cell lung cancer patients. [PDF]

Mol Oncol
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Zwierenga F, Dijkhuizen C, Korthuis P, Timens W, Groen H, Hiltermann J, van den Berg A, Drayer L, van der Wekken A.   +8 more
europepmc   +2 more sources

SLC34A2 Targets in Calcium/Phosphorus Homeostasis of Mammary Gland and Involvement in Development of Clinical Mastitis in Dairy Cows [PDF]

Animals
The type II Na/Pi co-transporter (NaPi2b), encoded by the solute carrier (SLC) transporter 34A2 (SLC34A2), is responsible for calcium (Ca) and phosphorus (P) homeostasis. Unbalanced Ca/P metabolism induces mastitis in dairy cows.
Xueying Wang, Bohao Zhang, Weitao Dong, Yu Zhao, Xingxu Zhao, Yong Zhang, Quanwei Zhang   +6 more
doaj   +2 more sources

T330M Substitution in the Sodium-Dependent Phosphate Transporter NaPi2b Abolishes the Efficacy of Monoclonal Antibodies Against MX35 Epitope [PDF]

Antibodies
Background: Monoclonal antibodies against the sodium-dependent phosphate transporter NaPi2b (SLC34A2) represent a promising approach in the treatment of ovarian and lung cancer.
Leisan F. Bulatova, Vera S. Skripova, Aisylu R. Sagdeeva, Ramilia A. Vlasenkova, Tatiana A. Bugaenko, Rezeda R. Galimova, Alfiya I. Nesterova, Yuliya V. Filina, Ramziya G. Kiyamova   +8 more
doaj   +2 more sources

Characterisation of phosphate transport in epididymis and prostate with possible relevance for semen qualityResearch in context [PDF]

EBioMedicine
Summary: Background: Seminal phosphate concentrations are markedly higher than serum levels, suggesting a yet uncharacterised role of phosphate transporters in the male reproductive tract.
Zhihui Cui, Sam Kafai Yahyavi, Ida Marie Boisen, Lasse Bøllehuus Hansen, Niels Jørgensen, Beate Lanske, Anders Juul, Mikkel Fode, Peter Busch Østergren, Thomas Hasselager, Anne Jørgensen, Martin Blomberg Jensen   +11 more
doaj   +2 more sources

Eight novel variants in theSLC34A2gene in pulmonary alveolar microlithiasis [PDF]

, 2019
BACKGROUND: Pulmonary alveolar microlithiasis (PAM) is caused by genetic variants in the SLC34A2 gene, which encodes the sodium-dependent phosphate transport protein 2B (NaPi-2b).
Åsa Jonsson, Elisabeth Bendstrup, Susie Mogensen, Elizabeth J. Kopras, Francis X. McCormack, Ilaria Campo, Francesca Mariani, Amparo Escribano-Montaner, Are Martin Holm, María del Mar Martínez-Colls, Guillem Pintos‐Morell, Camille Taillé, Bruno Crestani, Ole Hilberg, Jane Christensen, Ulf Simonsen   +15 more
openalex   +4 more sources

Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1

Kidney & Blood Pressure Research, 2015
Background/Aims: SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), kinases controlled by WNK (with-no-K[Lys] kinase), are powerful regulators of cellular ion transport and blood pressure.
Myriam Fezai, Bernat Elvira, Jamshed Warsi, Mossadok Ben-Attia, Zohreh Hosseinzadeh, Florian Lang   +5 more
doaj   +2 more sources

Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications [PDF]

eLife
Testicular microcalcifications consist of hydroxyapatite and have been associated with an increased risk of testicular germ cell tumors (TGCTs) but are also found in benign cases such as loss-of-function variants in the phosphate transporter SLC34A2 ...
Ida Marie Boisen, Nadia Krarup Knudsen, John E Nielsen, Ireen Kooij, Mathilde Louise Bagger, Jovanna Kaludjerovic, Peter O'Shaughnessy, Peter W Andrews, Noriko Ide, Birgitte G Toft, Anders Juul, Arnela Mehmedbasic, Anne Jørgensen, Lee B Smith, Richard Norman, Ewa Rajpert-De Meyts, Beate Lanske, Martin Blomberg Jensen   +17 more
doaj   +2 more sources

Pulmonary alveolar microlithiasis with minimal symptoms and near-complete whiteout on chest imaging [PDF]

Radiology Case Reports
Pulmonary alveolar microlithiasis (PAM) is a rare idiopathic disease characterized by accumulated calcium and phosphate crystals within the alveoli. Although PAM can be suspected in patients with clinical-radiological dissociation and characteristic ...
Nam Nguyen-Thanh, MD, Ngoc Duong-Minh, MD, Khoa Nguyen-Dang, MD, Thong Pham-Quang, MD, Nam Vu-Hoai, MD, PhD, Vu Le-Thuong, MD, PhD   +5 more
doaj   +2 more sources

Pulmonary alveolar microlithiasis: A case report with a novel mutation in the SLC34A2 gene and review of the literature

Human Pathology: Case Reports, 2018
Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive genetic disease characterized by intraalveolar psammomatous calcium phosphate deposition.
Caroline T. Simon, MD, Toby C. Lewis, MD, MPH, Fatima Neemuchwala, MD, Manuel Arteta, MD, Raja Rabah, MD   +4 more
doaj   +2 more sources

Long-Term Effects of Early Low-Phosphorous Nutritional Conditioning on Broiler Chicken Performance, Bone Mineralization, and Gut Health Under Adequate or Phosphorous-Deficient Diets. [PDF]

Animals (Basel)
Phosphorous is essential for many metabolic functions and the constitution of bones. Poultry have limited ability to use phosphorous from diets, which is mainly excreted and causes environmental concern. For this reason, diets are commonly supplemented
Tous N, Francesch M, Tarradas J, Badiola I, Pérez de Rozas AM, Fàbrega E, Ballester M, Quintanilla R, Torrallardona D.   +8 more
europepmc   +7 more sources