SLC34A2 inhibits tumorigenesis and progression via upregulating LRRK2/TTF-1/SELENBP1 axis in lung adenocarcinoma [PDF]
Cancer Gene TherAlveolar type II epithelial (AT2) cells have the properties of stem cells, abnormal AT2 cells serve as one of the original cells in lung adenocarcinoma (LUAD). However, the abnormal genes expression of AT2 cells during their malignant transformation into
Ying Zhu +8 more
semanticscholar +3 more sources
Eight novel variants in the SLC34A2 gene in pulmonary alveolar microlithiasis [PDF]
European Respiratory Journal, 2019 Background Pulmonary alveolar microlithiasis (PAM) is caused by genetic variants in the SLC34A2 gene, which encodes the sodium-dependent phosphate transport protein 2B (NaPi-2b).
Åsa Jonsson +15 more
semanticscholar +8 more sources
The Dolaflexin-based Antibody–Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b [PDF]
Molecular Cancer Therapeutics, 2021 Target selection for antibody–drug conjugates (ADC) frequently focuses on identifying antigens with differential expression in tumor and normal tissue, to mitigate the risk of on-target toxicity. However, this strategy restricts the possible target space.
Natalya D. Bodyak +23 more
semanticscholar +7 more sources
The effects and mechanisms of SLC34A2 on maintaining stem cell-like phenotypes in CD147 breast cancer stem cells [PDF]
Tumor Biology, 2017 The cancer stem cell (CSC) hypothesis has gained significant recognition in describing tumorigenesis. Identification of the factors critical to development of breast cancer stem cells (BCSCs) may provide insight into the improvement of effective ...
Yonggang Lv +14 more
doaj +4 more sources
High expression of SLC34A2 is a favorable prognostic marker in lung adenocarcinoma patients [PDF]
Tumor Biology, 2017 Dysregulation of SLC34A2 (NaPi2b) in tumors has attracted wide attention, but its expression and function in non–small cell lung cancer remains unclear.
Zhaoxuan Zhang +6 more
doaj +5 more sources
The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction [PDF]
Scientific Reports, 2017 NaPi-IIb/Slc34a2 is a Na+-dependent phosphate transporter that accounts for the majority of active phosphate transport into intestinal epithelial cells.
Thomas Knöpfel +7 more
semanticscholar +7 more sources
Human Pathology: Case Reports, 2018 Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive genetic disease characterized by intraalveolar psammomatous calcium phosphate deposition.
Caroline T. Simon, MD +4 more
doaj +4 more sources
A novel SLC34A2 mutation in a patient with pulmonary alveolar microlithiasis
Human Genome Variation, 2017 Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive disease caused by mutations in SLC34A2 and characterized by intra-alveolar accumulation of microliths.
Hiroki Izumi +8 more
semanticscholar +4 more sources
RESEARCH OF EXPRESSION MECHANISM OF SLC34A2 GENE AT PAM ALVEOLAR EPITHELIUM [PDF]
Chest, 2021 Yanbing Hu, Tiangang Ma, Qinghua Zhang
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A novel compound heterozygous mutation in the SLC34A2 gene causes pulmonary alveolar microlithiasis [PDF]
QJM: An International Journal of Medicine, 2023 Qingqing Liu +3 more
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