Results 71 to 80 of about 3,033 (181)
Histopathology, Volume 87, Issue 2, Page 223-234, August 2025.ROS1 antibody clones are not interchangeable in the breast cancer setting and highlight major discordances in ROS1 status according to antibody clone utilised. Aims Invasive lobular carcinoma (ILC) may show targetable vulnerabilities secondary to the characteristic loss of the cell adhesion protein E‐cadherin.
Anna Sokolova +9 more
wiley +1 more source
Успехи молекулярной онкологииIntroduction. The sodium-dependent phosphate transporter NaPi2b is a promising target for targeted antitumor therapy. There is the largest extracellular domain (ECD) containing a cryptic MX35 epitope, against which therapeutic antibodies have been ...
V. S. Skripova +5 more
doaj +1 more source
Clinical and Translational Science, Volume 18, Issue 7, July 2025.ABSTRACT We utilized an integrated approach for model‐informed dose selection to predict the recommended phase 2 dose (RP2D) of iruplinalkib, a selective oral ALK and ROS1 tyrosine kinase inhibitor. The efficacy and pharmacokinetics data obtained from ROS1 or ALK‐overexpressing cell‐derived xenograft models were used for pharmacokinetics ...
Guihong Yang +10 more
wiley +1 more source
Modern approaches in suicidal gene therapy of malignant neoplasms
Успехи молекулярной онкологииOne of the promising directions in antitumor therapy is suicidal gene therapy based on the introduction of cytotoxic genes into tumor cells. Most often, these genes encode for enzymes of bacterial or viral origin, capable of direct or indirect killing of
E. V. Dudkina +2 more
doaj +1 more source
1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine [PDF]
, 2021 Intestinal absorption of phosphate is stimulated by 1,25(OH)2 vitamin D3. At least two distinct mechanisms underlie phosphate absorption in the gut, an active transcellular transport requiring the Na+/phosphate cotransporter NaPi‐IIb/Slc34a2, and a ...
Carsten, W, Marks, J, Nati, H
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Disruption of mc1r Disturbs Skin Pigmentation in Xenopus tropicalis
Pigment Cell &Melanoma Research, Volume 38, Issue 4, July 2025.ABSTRACT The melanocortin 1 receptor (MC1R) is well‐established as a pivotal regulator of pigmentation in various species. Despite a wealth of research focused on mammals and fish, the role of Mc1r in amphibians has remained largely unexplored. This study was designed to elucidate the contribution of Mc1r in Xenopus tropicalis.
Lanxin Li +3 more
wiley +1 more source
Long non-coding RNA HAGLR inhibits growth and metastasis and reduces stemness of lung cancer cells through the microRNA-330-3p/SLC34A2 axis [PDF]
, 2020 Chunxia Yang +3 more
openalex +2 more sources
Pulmonary alveolar microlithiasis: two case reports and review of the literature [PDF]
European Respiratory Review, 2012 Pulmonary alveolar microlithiasis is a rare diffuse lung disease characterised by deposition of calcium phosphate within the alveolar airspaces. The disease is usually discovered from birth up to 40 yrs of age and is often diagnosed incidentally during ...
Elisabeth Bendstrup +3 more
doaj
La microlithiase alvéolaire: à propos d'une nouvelle observation
The Pan African Medical Journal, 2017 La microlithiase alvéolaire (MLA) est une affection rare, caractérisée par l'accumulation de concrétions calciques dans la lumière alvéolaire pulmonaire.
Nahid Zaghba +3 more
doaj +1 more source
Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP [PDF]
, 2018 We have recently shown that the abundance of the renal sodium (Na)/inorganic phosphate (Pi) cotransporter NaPi-IIa is increased in the absence of the GABAA receptor-associated protein (GABARAP).
Betz, Heinrich +5 more
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