Strategies Beyond 3rd EGFR‐TKI Acquired Resistance: Opportunities and Challenges
Cancer Medicine, Volume 14, Issue 9, May 2025.ABSTRACT The seminal identification of epidermal growth factor receptor (EGFR) mutations as pivotal oncogenic drivers in non‐small cell lung cancer (NSCLC) has catalyzed the evolution of biomarker‐guided therapeutic paradigms for advanced disease. Currently, third‐generation EGFR tyrosine kinase inhibitors (EGFR‐TKI) have revolutionized first‐line ...
Xuexue Zhou +7 more
wiley +1 more source
Transient DUX4 expression induces blastomere-like expression program that is marked by SLC34A2 [PDF]
, 2021 Masahito Yoshihara +14 more
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Dexamethasone and Cyclic AMP Regulate Sodium Phosphate Cotransporter (NaPi-IIb and Pit-1) mRNA and Phosphate Uptake in Rat Alveolar Type II Epithelial Cells [PDF]
, 2018 Alveolar epithelial type II (AT II) cells need phosphate (Pi) for surfactant synthesis. The Na-dependent (Nad) Pi transporters NaPi-IIb and Pit-1 are expressed in lung, but their expression, regulation, and function in AT II cells remain unclear.
Ghirlanda, Claudia +3 more
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A Real‐World Study: Therapeutic Outcomes of ROS1‐Positive Advanced NSCLC
Thoracic Cancer, Volume 16, Issue 9, May 2025.Flow chart illustrating the study design. We searched for cases of advanced NSCLC patients diagnosed with ROS1+ from July 2011 to November 2021 in our center. Patients who did not receive ROS1 inhibitor therapy were excluded. Forty cases were selected eventually. ROS1 diagnostic methods, treatment selection, and clinical outcomes were further analyzed.
Hanqi Yuan +6 more
wiley +1 more source
Pulmonary alveolar microlithiasis: no longer in the stone age
ERJ Open Research, 2020 Pulmonary alveolar microlithiasis (PAM) is a rare parenchymal lung disease caused by variants in the SCL34A2 gene and characterised by the accumulation of intra-alveolar microliths. PAM has been reported in fewer than 1100 cases throughout the world.
Elisabeth Bendstrup +1 more
doaj +1 more source
Pulmonary alveolar microlithiasis
Lung India, 2013 Pulmonary alveolar microlithiasis (PAM) is a rare, chronic lung disease with bilateral intra-alveolar calcium and phosphate deposition throughout the lung parenchyma with predominance to lower and midzone.
Surender Kashyap, Prasanta R Mohapatra
doaj +1 more source
BMC Cancer, 2020 Background The fine-needle aspiration (FNA) biopsy was broadly applied to clinical diagnostics evaluation for thyroid carcinomas nodule, while companioning with higher uncertainty rate (15~30%) to identify malignancy for cytological indeterminate cases ...
Dandan Wu +4 more
doaj +1 more source
Characterization of inorganic phosphate transport in the triple-negative breast cancer cell line, MDA-MB-231. [PDF]
PLoS ONE, 2018 Recent studies demonstrate that interstitial inorganic phosphate is significantly elevated in the breast cancer microenvironment as compared to normal tissue.
Thais Russo-Abrahão +9 more
doaj +1 more source
Retraction Note: Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway [PDF]
, 2022 Jiaxing Zhang +8 more
openalex +1 more source
Unchanged expression of the sodium-dependent phosphate cotransporter NaPi-IIa despite diurnal changes in renal phosphate excretion [PDF]
, 2018 Renal phosphate excretion is subjected to circadian rhythmicity. The bulk of filtered inorganic phosphate (Pi) is reabsorbed by the sodium-dependent phosphate cotransporter NaPi-IIa.
Bacic, Desa +5 more
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