Results 91 to 100 of about 2,192 (190)

Natural Hydrogels Support Kidney Organoid Generation and Promote In Vitro Angiogenesis

Advanced Materials, Volume 36, Issue 34, August 22, 2024.
Natural hydrogels derived from decellularized porcine or human kidney tissues are used to generate kidney organoids from human pluripotent stem cells, resulting in the enrichment of organoids’ endogenous vascular component and improved renal differentiation. Exploiting the autonomous capacity of kidney organoids to exhibit endogenous vascularization in
Elena Garreta, Daniel Moya‐Rull, Andrés Marco, Gaia Amato, Asier Ullate‐Agote, Carolina Tarantino, Maria Gallo, David Esporrín‐Ubieto, Alberto Centeno, Amaia Vilas‐Zornoza, Rafael Mestre, María Kalil, Izar Gorroñogoitia, Ane Miren Zaldua, Samuel Sanchez, Laura Izquierdo Reyes, María Eugenia Fernández‐Santos, Felipe Prosper, Nuria Montserrat   +18 more
wiley   +1 more source

Nurr1 protein is required for N-Methyl-d-aspartic Acid (NMDA) receptor-mediated neuronal survival [PDF]

, 2012
NMDA receptor (NMDAR) stimulation promotes neuronal survival during brain development. Cerebellar granule cells (CGCs) need NMDAR stimulation to survive and develop.
Badiola Benito, Nahuai, Barneda Zahonero, Bruna, Fadó, Rut, Miñano Molina, Alfredo Jesús, Rodríguez Álvarez, José, Saura Antolín, Carlos A., Servitja i Duque, Joan-Marc   +6 more
core   +2 more sources

Prenatal diagnosis of cystinuria with a heterozygous pathogenic variant in SLC7A9 gene associated with isolated hyperechogenic fetal kidneys: A case report

Clinical Case Reports, Volume 12, Issue 7, July 2024.
Sagittal US scans of the left (A) and right (B) kidneys at 21 weeks and 6 days of gestation showing bilateral hyperechogenic nondifferentiated kidneys of normal size. Key Clinical Message Cystinuria is suspected antenatally by a hyperechogenic fetal colonic content.
Osaretin Pamela Aigbogun, Noémie Vancoppenolle, Sandra Coppens, Martina Marangoni, Elodie Elsen, Marie Cassart, Caroline Gounongbe   +6 more
wiley   +1 more source

Renal Fanconi Syndrome and Hypophosphatemic Rickets in the Absence of Xenotropic and Polytropic Retroviral Receptor in the Nephron. [PDF]

, 2017
Tight control of extracellular and intracellular inorganic phosphate (Pi) levels is critical to most biochemical and physiologic processes. Urinary Pi is freely filtered at the kidney glomerulus and is reabsorbed in the renal tubule by the action of the ...
Baron, R., Gautschi, I., Haenzi, B., Hu, D.Z., Katanaev, V., Katanaeva, N., Koesters, R., Nikolaeva, S., Pradervand, S., Rotman, S., Schild, L.   +10 more
core   +1 more source

Primary mitochondrial disorders and mimics: Insights from a large French cohort

Annals of Clinical and Translational Neurology, Volume 11, Issue 6, Page 1478-1491, June 2024.
Abstract Objective The objective of this study was to evaluate the implementation of NGS within the French mitochondrial network, MitoDiag, from targeted gene panels to whole exome sequencing (WES) or whole genome sequencing (WGS) focusing on mitochondrial nuclear‐encoded genes.
Cécile Rouzier, Emmanuelle Pion, Annabelle Chaussenot, Céline Bris, Samira Ait‐El‐Mkadem Saadi, Valérie Desquiret‐Dumas, Naïg Gueguen, Konstantina Fragaki, Patrizia Amati‐Bonneau, Giulia Barcia, Pauline Gaignard, Julie Steffann, Alessandra Pennisi, Jean‐Paul Bonnefont, Elise Lebigot, Sylvie Bannwarth, Bruno Francou, Benoit Rucheton, Damien Sternberg, Marie‐Laure Martin‐Negrier, Aurélien Trimouille, Gaëlle Hardy, Stéphane Allouche, Cécile Acquaviva‐Bourdain, Cécile Pagan, Anne‐Sophie Lebre, Pascal Reynier, Mireille Cossee, Shahram Attarian, Véronique Paquis‐Flucklinger, MitoDiag's Network Collaborators, Vincent Procaccio   +31 more
wiley   +1 more source

Clinical and molecular characterization of cystinuria in a French cohort: relevance of assessing large-scale rearrangements and splicing variants. [PDF]

, 2017
Cystinuria is an autosomal recessive disorder of dibasic amino acid transport in the kidney and the intestine leading to increased urinary cystine excretion and nephrolithiasis.
Adzhubei, Albers, Auer, Auton, Barbosa, Bisceglia, Bisceglia, Botzenhart, Brasseur-Daudruy, Brauers, Buxmann, Calonge, Chatzikyriakidou, Chillaron, Dello Strologo, Di Giacomo, Eggermann, Endsley, Feliubadalo, Font, Font-Llitjos, Gaildrat, Gasparini, Gitomer, Harnevik, Horsford, Houdayer, Jaeken, Ke, Kumar, Kummer, Leclerc, Lee, Lek, Lim, Martens, Palacin, Pras, Pras, Prezioso, Reig, Saadi, Schmidt, Schwarz, Skopkova, Soukarieh, Stenson, Tarailo-Graovac, Tavtigian, Tournier, Wong, Yeo   +51 more
core   +3 more sources

Comparative analysis of genetic testing utilization rates among people with and without disabilities in South Korea from 2016 to 2019, focusing on malignant neoplasms: A national population‐based study

Cancer Medicine, Volume 13, Issue 9, May 2024.
Abstract Introduction Oncogene testing is widely used to detect or direct cancer treatments. Compared to people without disabilities, people with disabilities in Korea have a lower cancer incidence rate but a fivefold higher cancer mortality rate, implying delayed detection.
Gwanwook Bang, Minji Park, Jeong‐yeon Seon, So‐Youn Park   +3 more
wiley   +1 more source

Exploring the effect of feeding broiler chickens a diet incorporating unfermented or fermented palm kernel cake: growth performance, digestibility, biochemical indices, digestive enzyme activity, and mRNA gene expression of nutrient transporters

Italian Journal of Animal Science
This study evaluated the effect of substituting corn and soybeans in broiler chickens’ diets by incorporating unfermented or fermented palm kernel cake (PKC).
Sindaye Daniel, Shehata Zeid, Liao Jinghong, Suqin Hang   +3 more
doaj   +1 more source

The macrocycle inhibitor landscape of SLC‐transporter

Molecular Informatics, Volume 43, Issue 5, May 2024.
Abstract In the past years the interest in Solute Carrier Transporters (SLC) has increased due to their potential as drug targets. At the same time, macrocycles demonstrated promising activities as therapeutic agents. However, the overall macrocycle/SLC‐transporter interaction landscape has not been fully revealed yet.
Nejra Granulo, Sergey Sosnin, Daniela Digles, Gerhard F. Ecker   +3 more
wiley   +1 more source

Kidney amino acid transport [PDF]

, 2018
Near complete reabsorption of filtered amino acids is a main specialized transport function of the kidney proximal tubule. This evolutionary conserved task is carried out by a subset of luminal and basolateral transporters that together form the ...
Camargo, Simone, Mariotta, Luca, Ramadan, Tamara, Singer, Dustin, Verrey, François, Vuille-dit-Bille, Raphael   +5 more
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