Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma [PDF]
Molecular OncologySquamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor‐initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis.
Johan Staaf +10 more
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The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression [PDF]
Advanced ScienceCancer‐associated fibroblasts (CAFs) dominate the tumor stroma in colorectal cancer (CRC), fostering an immunosuppressive microenvironment that supports tumor growth, metastasis, and therapy resistance.
Jiahua Yu +5 more
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[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation [PDF]
Scientific ReportsPathogenic variants in the creatine transporter gene SLC6A8, reported to represent 2% of all intellectual disabilities in males, result in a spectrum of behavioral abnormalities including developmental delay, intellectual disability, and deficit in ...
Isabel Day +8 more
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Targeting SLC6A8 suppresses tumor growth and enhances ferroptosis in hepatocellular carcinoma [PDF]
Journal of Cancer Research and Clinical OncologyBackground Hepatocellular carcinoma (HCC) persists as a therapeutic challenge owing to restricted treatment alternatives and the dearth of effective biomarkers.
Wenfang Bao +5 more
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Multiple machine learning algorithms identified SLC6A8 as a diagnostic biomarker of the late stage of Hepatocellular carcinoma [PDF]
Discover OncologyHepatocellular carcinoma (HCC) is a chronic liver disease characterized by persistent tumor growth, contributing significantly to mortality rates worldwide.
Linlin Song, Hongli Zhang, Wang Yang
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Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency [PDF]
Acta Neuropathologica Communications, 2023 Mutations in the solute carrier family 6-member 8 (Slc6a8) gene, encoding the protein responsible for cellular creatine (Cr) uptake, cause Creatine Transporter Deficiency (CTD), an X-linked neurometabolic disorder presenting with intellectual disability,
Elsa Ghirardini +15 more
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Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology [PDF]
eLife, 2023 The discovery of a new neurotransmitter, especially one in the central nervous system, is both important and difficult. We have been searching for new neurotransmitters for 12 y.
Xiling Bian +7 more
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Evaluation of SLC6A8 species conservation and the effect of pathogenic variants on creatine transport [PDF]
HGG AdvancesSummary: Creatine phosphate is a high-energy molecule essential for the normal functioning of highly metabolically active organs and tissues. SLC6A8 encodes the only known creatine transporter in humans (CRT1); pathogenic variants result in a ...
Taryn Diep, Gerald S. Lipshutz
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Intratesticular creatine maintains spermatogenesis by defining tight junctions [PDF]
Scientific ReportsOne in five couples who wish to conceive is infertile, and half of these couples have male infertility. However, the causes of male infertility are still largely unknown.
Sohei Kuribayashi +8 more
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Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency [PDF]
eLife, 2023 Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the SLC6A8 gene. The impaired creatine uptake in the brain results in intellectual disability, behavioral disorders, language delay, and seizures.
Léa Broca-Brisson +15 more
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