Results 1 to 10 of about 298,412 (99)

Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency [PDF]

Frontiers in Molecular Neuroscience, 2023
Creatine transporter deficiency (CTD), a leading cause of intellectual disability is a result of the mutation in the gene encoding the creatine transporter SLC6A8, which prevents creatine uptake into the brain, causing mental retardation, expressive ...
Aloise Mabondzo, Jean Armengaud, Matthew Skelton   +2 more
exaly   +4 more sources

Dodecyl Creatine Ester-Loaded Nanoemulsion as a Promising Therapy for Creatine Transporter Deficiency [PDF]

Nanomedicine, 2019
Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations of CrT. This work focus on the preclinical development of a new therapeutic approach based on a microemulsion (ME) as drug delivery system for dodecyl ...
Alain Pruvost, Kenea Udobi, Matthew Skelton   +2 more
exaly   +4 more sources

Epigenetic alterations in creatine transporter deficiency: a new marker for dodecyl creatine ester therapeutic efficacy monitoring [PDF]

Frontiers in Neuroscience
Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the Slc6a8 gene. The impaired creatine uptake in the brain leads to developmental delays with intellectual disability.
Aloise Mabondzo, Lea Broca-Brisson
exaly   +4 more sources

Mitochondrial Mediated Apoptosis Evaluation of Myristicin on Triple Negative Breast Cancer Model Via Bcl2/Bid Pathway. [PDF]

Cell Biochem Funct
ABSTRACT Among 15‐20 cases of breast cancer, triple‐negative breast cancer (TNBC) is the deadliest form of the disease. The most effective form of treatment for this type of cancer is still targeted chemotherapy because it lacks hormone receptors. Myristicin, an active aromatic compound with anticancer properties, is mostly found in nutmeg.
Nazar SS, Ajaykumar AV, Ayyappan JP.
europepmc   +2 more sources

Systematic Pharmacology Combined With Experimental Validation Reveals the Apoptosis-Related Mechanism of Simiao Yong'an (SMYA) Decoction Against Myocardial Ischemia-Reperfusion Injury. [PDF]

Cardiovasc Ther
Background According to traditional Chinese medicine theory, acute myocardial infarction (AMI) is primarily associated with qi stagnation and blood stasis. Simiao Yong′an (SMYA) decoction is a well‐known prescription that clears heat, detoxifies, and promotes blood circulation.
Fu H, Liu E, Yu H, Zhao Y, Gan Y, Chen J, Liu Z.   +6 more
europepmc   +2 more sources

Engineered exosomes improve myocardial cell membrane integrity and heart function in dystrophic cardiomyopathy. [PDF]

Clin Transl Med
Schematic diagram of the manufacturing process of exosomes‐cardiac homing peptide (Exo‐CHP) and its therapeutic effects for Duchenne muscular dystrophy (DMD) cardiomyopathy. Abstract Background Duchenne muscular dystrophy (DMD)‐associated cardiomyopathy is a leading causes of premature death, yet treatment options remain limited.
Wu Q, Xue Y, Zhang K, Xu K, Xu T, Fu H, Zhang S, Zhang M, Sun R, Shan Chan SH, Zhou L, Cai X, Guo Y, Xu H.   +13 more
europepmc   +2 more sources

Dietary essential oils modulate post-mortem oxidative damage in trout fillets exposed to slaughter stress during frozen storage. [PDF]

J Sci Food Agric
Abstract BACKGROUND Slaughter is a critical phase in aquaculture that can severely compromise both animal welfare and product quality. Stress responses triggered during this stage may accelerate post‐mortem biochemical degradation and promote oxidative damage in fish fillets. Essential oils, known for their antioxidant and anti‐inflammatory properties,
Méndez L, Secci G, Barros L, Dasilva G, Parisi G, Medina I.   +5 more
europepmc   +2 more sources

Dual-Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti-Inflammatory and Anti-Fibrotic Effects. [PDF]

Adv Sci (Weinh)
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Zhang H, Li J, Hua S, Wu S, He C, Zhu Y, Yin M, Zhou H, Liu H, Hasegawa C, Lyu J, Xiao K, Jiang H, Wang Y, Qian Y.   +14 more
europepmc   +2 more sources

CK2α Deficiency Drives Myocardial Fibrosis via Desmin-Induced Mitochondrial Dysfunction. [PDF]

Adv Sci (Weinh)
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Ma C, Jia J, Lan J, Wang J, Rao D, Rao L, Zhang W, Wu D, Zhang J, Wang G, Liu B, Ao Y, Wang Z.   +12 more
europepmc   +2 more sources

A Mediterranean Diet-Based Food Mix Ameliorates Diabetes- and Obesity-Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming. [PDF]

Mol Nutr Food Res
Metabolic syndrome (MetS)‐related conditions are key factors in liver damage. A Mediterranean lifestyle shows promise in managing MetS, though its mechanisms remain unclear. This study tested a lab‐designed food mix mimicking the 1960s Mediterranean Diet (MD) on obese and diabetic mice; it prevented hyperlipidemia and reduced oxidative liver damage ...
Mercurio G, Giacco A, Troise AD, Ledbetter M, De Pascale S, Scopigno N, Vigliotti M, Mazzola M, Riccio G, Scaloni A, Moreno M, Fiore A, Cioffi F, Silvestri E.   +13 more
europepmc   +2 more sources