Results 31 to 40 of about 745 (89)

Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin‐2 dephosphorylation and impairing mitochondrial quality control

Clinical and Translational Medicine, Volume 14, Issue 8, August 2024.
Pgam5 knockout attenuates alcohol‐induced cardiac histopathology and heart dysfunction in male mice. Pgam5 interacts with Phb2 and induces Phb2 dephosphorylation. Disruption of Pgam5/Phb2 binding reduces EtOH‐induced mitochondrial quality control impairment in cardiomyocytes. Mice genetically modified to express a phosphor‐mimetic Phb2 mutant at serine
Jun Tao, Junxiong Qiu, Junmeng Zheng, Ruibing Li, Xing Chang, Qingyong He   +5 more
wiley   +1 more source

Recent Trends of Bioanalytical Sensors with Smart Health Monitoring Systems: From Materials to Applications

Advanced Healthcare Materials, Volume 13, Issue 17, July 5, 2024.
This review summarizes key issues and offers suggestions for the novel use and integration of smart biosensors in real‐time health monitoring process, as well as provides insight into their material functionality and technological approaches. With smart established systems, bioelectronics can be able to accurately provide capabilities for diagnosing ...
Thi Sinh Vo, Trung Hoang, Tran Thi Bich Chau Vo, Byounghyun Jeon, Vu Hoang Nguyen, Kyunghoon Kim   +5 more
wiley   +1 more source

In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery

Advanced Therapeutics, Volume 7, Issue 2, February 2024.
Encapsulins are prokaryotic protein nanocages that show promise as nanoparticle‐based drug delivery systems. However, the in vivo behavior of encapsulins is poorly understood. This study elucidates the formulability, nanosafety, immunogenicity, protein corona, biodistribution, and clearance of intravenously injected nanocages.
Claire Rennie, Caitlin Sives, India Boyton, Dennis Diaz, Catherine Gorrie, Orazio Vittorio, Lyndsey Collins‐Praino, Andrew Care   +7 more
wiley   +1 more source

Electrochemical Biosensors Based on Enzyme Inhibition Effect

The Chemical Record, Volume 24, Issue 2, February 2024.
Several electrochemical biosensors based on various enzyme inhibition effects have been designed; their laboratory prototypes have been manufactured and thoroughly investigated. It should be noted that such biosensors are adapted to large‐scale production technologies.
Valentyna Arkhypova, Oleksandr Soldatkin, Alexei Soldatkin, Sergei Dzyadevych   +3 more
wiley   +1 more source

Loss of nephric augmenter of liver regeneration facilitates acute kidney injury via ACSL4‐mediated ferroptosis

Journal of Cellular and Molecular Medicine, Volume 28, Issue 3, February 2024.
Abstract Ferroptosis, characterized by lipid accumulation in intracellular compartments, is related to acute kidney injury (AKI), but the mechanism remains obscure. In our previous study, the protective effect of augmenter of liver regeneration (ALR) on AKI was not fully clarified.
Lili Huang, Ling Zhang, Zheng Zhang, Fangyan Tan, Yixin Ma, Xujia Zeng, Dan Cao, Lili Deng, Qi Liu, Hang Sun, Bingbing Shen, Xiaohui Liao   +11 more
wiley   +1 more source

Chemical optimization of creatine derivatives for the treatment of creatine transporter deficiency

, 2013
Le déficit en transporteur de la créatine est une maladie rare neurologique dans laquelle la perte de fonctionnalité du transporteur de la créatine (SLC6A8) conduit à une absence de créatine au niveau cérébral et à des retards de développement majeurs ...
Trotier-Faurion, Alexandra
core  

Editorial: Advances in brain disorders: from mechanisms to therapeutic targets. [PDF]

Front Mol Neurosci, 2023
Bono F, Abate G, Bonini SA, Sisalli MJ, Bellucci A.   +4 more
europepmc   +1 more source

Neuroimaging tools for monitoring brain functions in neurodevelopmental diseases

The aim of this project was to evaluate the Intrinsic Optical Signal (IOS) response as a possible biomarker for neurodevelopmental diseases, specifically for Creatine Transporter Deficiency (CTD) and Fragile X Syndrome (FXS).
MORROCCHESI, LORENZO
core  

CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport. [PDF]

Oncoimmunology, 2023
Tian C, Yuan H, Lu Y, He H, Li Q, Li S, Yang J, Wang M, Xu R, Liu Q, Xiang M.   +10 more
europepmc   +1 more source

State of the Art and Development Trends in Obtaining Fast-Dissolving Forms of Creatine Monohydrate. [PDF]

Pharmaceuticals (Basel)
Albagachiev SA, Pinegina ED, Sadkovskii IA, Krasnyuk II, Mandrik MA.   +4 more
europepmc   +1 more source