Results 11 to 20 of about 745 (89)

Dodecyl Creatine Ester Improves Cognitive Function and Identifies Drivers of Creatine Deficiency

, 2022
Abstract Creatine transporter deficiency prevents creatine uptake into the brain, leading to mental retardation. To better understand the pathophysiology, this study focuses on the identification of biomarkers related to cognitive improvement in a Slc6a8 knockout mouse model (Slc6a8/y) engineered to mimic the clinical features of CTD ...
Aloïse Mabondzo, Rania Harati, Léa Broca-Brisson, Anne-Cécile Guyot, Narciso Costa, Francesco Cacciante, Elena Putignano, Laura Baroncelli, Matthew R Skelton, Cathy Saab, Emmanuelle Martini, Henri Benech, Thomas Joudinaud, Jean-Charles Gaillard, Jean Armengaud, Rifat A. Hamoudi   +15 more
openaire   +2 more sources

Systematic Pharmacology Combined With Experimental Validation Reveals the Apoptosis-Related Mechanism of Simiao Yong'an (SMYA) Decoction Against Myocardial Ischemia-Reperfusion Injury. [PDF]

Cardiovasc Ther
Background According to traditional Chinese medicine theory, acute myocardial infarction (AMI) is primarily associated with qi stagnation and blood stasis. Simiao Yong′an (SMYA) decoction is a well‐known prescription that clears heat, detoxifies, and promotes blood circulation.
Fu H, Liu E, Yu H, Zhao Y, Gan Y, Chen J, Liu Z.   +6 more
europepmc   +2 more sources

Dietary essential oils modulate post-mortem oxidative damage in trout fillets exposed to slaughter stress during frozen storage. [PDF]

J Sci Food Agric
Abstract BACKGROUND Slaughter is a critical phase in aquaculture that can severely compromise both animal welfare and product quality. Stress responses triggered during this stage may accelerate post‐mortem biochemical degradation and promote oxidative damage in fish fillets. Essential oils, known for their antioxidant and anti‐inflammatory properties,
Méndez L, Secci G, Barros L, Dasilva G, Parisi G, Medina I.   +5 more
europepmc   +2 more sources

A Mediterranean Diet-Based Food Mix Ameliorates Diabetes- and Obesity-Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming. [PDF]

Mol Nutr Food Res
Metabolic syndrome (MetS)‐related conditions are key factors in liver damage. A Mediterranean lifestyle shows promise in managing MetS, though its mechanisms remain unclear. This study tested a lab‐designed food mix mimicking the 1960s Mediterranean Diet (MD) on obese and diabetic mice; it prevented hyperlipidemia and reduced oxidative liver damage ...
Mercurio G, Giacco A, Troise AD, Ledbetter M, De Pascale S, Scopigno N, Vigliotti M, Mazzola M, Riccio G, Scaloni A, Moreno M, Fiore A, Cioffi F, Silvestri E.   +13 more
europepmc   +2 more sources

A Nonketotic Hyperglycinemia Mouse Shows Wide-Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One-Carbon Charging, and Serine Deficiency. [PDF]

J Inherit Metab Dis
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Swanson MA, Jiang H, Kolora LD, Molino R, Reisdorph R, Michel CR, Doenges KA, Leung KY, Lin X, Wong F, Lancaster S, Michael B, Snyder M, Hock DH, Stroud DA, Wood T, Binard R, Anderson-Lehman L, Christians U, Arning E, Friederich MW, Van Hove RA, MacLean KN, Greene NDE, Van Hove JLK.   +24 more
europepmc   +2 more sources

Data_Sheet_1_Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency.zip

, 2023
Creatine transporter deficiency (CTD), a leading cause of intellectual disability is a result of the mutation in the gene encoding the creatine transporter SLC6A8, which prevents creatine uptake into the brain, causing mental retardation, expressive ...
Emmanuelle Martini (203348), Henri Benech (1963210), Rania Harati (1963207), Jean Armengaud (16857), Elena Putignano (29416), Anne-Cécile Guyot (6091409), Jean-Charles Gaillard (1696402), Aloïse Mabondzo (3553712), Francesco Cacciante (14836711), Thomas Joudinaud (14836717), Laura Baroncelli (29417), Matthew R. Skelton (357788), Léa Broca-Brisson (14836705), Narciso Costa (14836708), Rifat Hamoudi (523339), Cathy Saab (14836714)   +15 more
core   +1 more source

Updated safety evaluation of the food enzyme phospholipase A₂ from the genetically modified <i>Trichoderma reesei</i> strain RF8793. [PDF]

EFSA J
Abstract The food enzyme phospholipase A2 (phosphatidylcholine 2‐acylhydrolase; EC 3.1.1.4) is produced with the genetically modified Trichoderma reesei strain RF8793 by AB Enzymes GmbH. In a previous opinion, the total organic solids (TOS) values could not be calculated, which led to the inability to establish the representativeness of the batch used ...
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano M, Van Loveren H, Vernis L, Criado A, Liu Y.   +14 more
europepmc   +2 more sources

Echinococcus granulosus antigen B regulates T-cell function through inhibition of signal transducer and activator of transcription 3 in experimental immune thrombocytopenia. [PDF]

Br J Haematol
During the pathological process of immune thrombocytopenia, signal transducer and activator of transcription 3 (STAT3) is activated by JAKs, leading to the production of a large number of inflammatory cytokines and promoting the activation of Th1, Th2 and Th17 cells.
Yue Y, Zhang Y, Cheng Y, Jiao H, Yan M.
europepmc   +2 more sources

Synthesis and Biological Evaluation of New Creatine Fatty Esters Revealed Dodecyl Creatine Ester as a Promising Drug Candidate for the Treatment of the Creatine Transporter Deficiency

, 2016
The creatine transporter deficiency is a neurological disease caused by impairment of the creatine transporter SLC6A8, resulting in mental retardation associated with a complete absence of creatine within the brain and cellular energy perturbation of ...
Aloïse Mabondzo (1942075), Alexandra Trotier-Faurion (1942078), Frédéric Taran (1688335), Vassili Valayannopoulos (1942084), Pascale de Lonlay (1942081), Sophie Dézard (1942072)   +5 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source