Intranasal delivery of dodecyl creatine ester alleviates motor deficits and increases dopamine levels in a 6-OHDA rat model of parkinsonism [PDF]
Frontiers in Aging NeuroscienceINTRODUCTION: Creatine has been recognized not only as an energy buffer but also for its antioxidant, antiapoptotic, and anti-excitotoxic properties, making it of interest as a neuroprotective agent.
Aloise Mabondzo +2 more
exaly +3 more sources
New Insights into Drug Development via the Nose-to-Brain Pathway: Exemplification Through Dodecyl Creatine Ester for Neuronal Disorders [PDF]
PharmaceuticsBrain disorders remain a major global health challenge, highlighting the urgent need for innovative therapeutic strategies and efficient drug-delivery approaches.
Henri Benech
exaly +3 more sources
Effects of whey isolate, creatine and resistance training on muscle hypertrophy [PDF]
, 2007 PURPOSE: Studies that have attributed gains in lean body mass to dietary supplementation during RE training have not reported these changes alongside adaptations at the cellular and sub-cellular levels. Therefore, the purpose of this study was to examine
Carey, Michael F +4 more
core +6 more sources
Dodecyl creatine ester therapy: from promise to reality [PDF]
Cellular and Molecular Life SciencesAloise Mabondzo +1 more
exaly +2 more sources
Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine. [PDF]
, 2011 Over the past four or five decades, there has been increasing interest in the neurochemical regulation of cognition. This field received considerable attention in the 1980s, with the identification of possible cognition enhancing agents or "smart drugs".
Sünram-Lea, Sandra-Ilona, Owen, Lauren
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Dodecyl creatine ester and lipid nanocapsule: a double strategy for the treatment of creatine transporter deficiency. [PDF]
, 2014 Background: Creatine transporter (CT) deficiency is characterized by mutations in the gene encoding CT, leading to impaired transport of creatine at the cell membrane.
S. Dézard +17 more
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Creatine protects against excitoxicity in an in vitro model of neurodegeneration. [PDF]
, 2012 Creatine has been shown to be neuroprotective in aging, neurodegenerative conditions and brain injury. As a common molecular background, oxidative stress and disturbed cellular energy homeostasis are key aspects in these conditions. Moreover, in a recent
Geiger Johanna +17 more
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, 2016 The creatine transporter deficiency is a neurological disease caused by impairment of the creatine transporter SLC6A8, resulting in mental retardation associated with a complete absence of creatine within the brain and cellular energy perturbation of ...
Aloïse Mabondzo (1942075) +5 more
core +1 more source
, 2023 Creatine transporter deficiency (CTD), a leading cause of intellectual disability is a result of the mutation in the gene encoding the creatine transporter SLC6A8, which prevents creatine uptake into the brain, causing mental retardation, expressive ...
Emmanuelle Martini (203348) +15 more
core +1 more source
Metal‐Dependent Effects and Crowding Robustness of Pseudomonas fluorescens Esterase I
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Pseudomonas fluorescens esterase I retains catalytic activity in metal‐rich and crowded environments, despite metal‐specific inhibitory effects. These findings highlight its robustness for biocatalytic applications in complex environments. Industrial biocatalysts are strongly influenced by their physicochemical environment, yet systematic studies on ...
Emmanouil Ntermanakis +6 more
wiley +1 more source