Results 21 to 30 of about 745 (89)

Développement d'organoïdes cérébraux de patients atteints du déficit en transporteur de la créatine comme outil d'évaluation de l'efficacité d'agents thérapeutiques

, 2023
Creatine transporter deficiency (CTD) is a rare genetic and metabolic disorder in which loss of functionality of the creatine transporter (CRT, SLC6A8) leads to an absence of creatine in the brain.
Broca-Brisson, Léa
core   +1 more source

Metal‐Dependent Effects and Crowding Robustness of Pseudomonas fluorescens Esterase I

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Pseudomonas fluorescens esterase I retains catalytic activity in metal‐rich and crowded environments, despite metal‐specific inhibitory effects. These findings highlight its robustness for biocatalytic applications in complex environments. Industrial biocatalysts are strongly influenced by their physicochemical environment, yet systematic studies on ...
Emmanouil Ntermanakis, Nikoleta Syngelaki, Alexandros Lyratzakis, Renia Fotiadou, Spyridoula Charova, Ioannis V. Pavlidis, Angeliki Giannouli   +6 more
wiley   +1 more source

Proteomic and Super‐Resolution Analyses of Murine Brown Adipocyte‐Derived Extracellular Vesicles

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
Graphical Abstract ABSTRACT Thermogenic brown adipocytes (BAs) are not only an energy sink but also regulate systemic metabolic health through secreted factors and extracellular vesicles (EVs). Here, we investigate the baseline profiles BA‐EVs and how cold‐induced thermogenesis alters the proteome of BA‐EVs.
Menchus Quan, Yi‐Kai Liu, Maryam Mahmoodi, Muhammad Asif, Madeline Kay, Yongjie Yang, Fang Huang, Weiguo Andy Tao, Shihuan Kuang   +8 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Optimisation pharmacologique des dérivés de la créatine pour le traitement du déficit en transporteur de la créatine

, 2013
Creatine transporter deficiency is a rare brain disease associated with the loss of function of the SLC6A8 (creatine transporter) leading to an absence of creatine at the cerebral level and to a dramatic neurodevelopmental retardation in the children. To
Trotier-Faurion, Alexandra
core   +2 more sources

Development of brain organoids from patients with creatine transporter deficiency as a tool for evaluating the efficacy of therapeutic agents

, 2023
Le déficit en transporteur de la créatine (CTD) est une maladie génétique et métabolique rare dans laquelle la perte de fonctionnalité du transporteur de la créatine (CRT, SLC6A8) conduit à une absence de créatine dans le cerveau.
Broca-Brisson, Léa
core  

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

Journal of Applied Toxicology, Volume 45, Issue 8, Page 1455-1475, August 2025.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz, Shira Paz, Rotem Saban, Inbar Zuker, Hagay Shmuely, Katy Gorshkov, Jwar Meetro, Shahrzad Tafazoli, Trung Vo, Gabriela Amiram, Carmit Shani Levi, Uri Lesmes, Ilan Samish   +12 more
wiley   +1 more source

Biochemical and Biological Profiles of Bangladeshi Russell’s Viper Snake Venom and Neutralizing Efficacy by Indian VINS Polyvalent Antivenom

Journal of Toxicology, Volume 2025, Issue 1, 2025.
The Russell’s viper (Daboia russelii) has recently become a significant threat to human life in Bangladesh. Given its wide distribution across South Asia, the venom characteristics and lethality can vary by region with different toxicological properties.
Rubait Hasan, Hasanuzzaman Manik, Md Ataur Rahman, Jamiatul Husna Shathi, Md Tariqul Islam, Mohammad Shahangir Biswas, Kazi Md. Faisal Hoque, Phuping Sucharitakul   +7 more
wiley   +1 more source

Transcriptome Analysis of Myocardial Ischemic‐Hypoxic Injury in Rats and Hypoxic H9C2 Cells

ESC Heart Failure, Volume 11, Issue 6, Page 3775-3795, December 2024.
Abstract Aims This study aimed to address inconsistencies in results between the H9C2 myocardial hypoxia (MH) cell line and myocardial infarction (MI) rat models used in MI research. We identified differentially expressed genes (DEGs) and underlying molecular mechanisms using RNA sequencing technology. Methods RNA sequencing was used to analyse DEGs in
Nan Niu, Huangtai Miao, Hongmei Ren
wiley   +1 more source

Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs

Allergy, Volume 79, Issue 12, Page 3238-3268, December 2024.
Abstract Since the 1960s, more than 350,000 new chemicals have been introduced into the lives of humans and domestic animals. Many of them have become part of modern life and some are affecting nature as pollutants. Yet, our comprehension of their potential health risks for both humans and animals remains partial.
Sena Ardicli, Ozge Ardicli, Duygu Yazici, Yagiz Pat, Huseyn Babayev, Peng Xiong, Can Zeyneloglu, Asuncion Garcia‐Sanchez, Li‐Li Shi, Oliva Giannelli Viscardi, Stephen Skolnick, Ismail Ogulur, Raja Dhir, Marek Jutel, Ioana Agache, Jozef Janda, Isabella Pali‐Schöll, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis   +19 more
wiley   +1 more source