[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation [PDF]
Scientific ReportsPathogenic variants in the creatine transporter gene SLC6A8, reported to represent 2% of all intellectual disabilities in males, result in a spectrum of behavioral abnormalities including developmental delay, intellectual disability, and deficit in ...
Gerald Lipshutz +2 more
exaly +5 more sources
Evaluation of SLC6A8 species conservation and the effect of pathogenic variants on creatine transport [PDF]
Human Genetics and Genomics AdvancesSummary: Creatine phosphate is a high-energy molecule essential for the normal functioning of highly metabolically active organs and tissues. SLC6A8 encodes the only known creatine transporter in humans (CRT1); pathogenic variants result in a ...
Gerald Lipshutz
exaly +5 more sources
Targeting SLC6A8 suppresses tumor growth and enhances ferroptosis in hepatocellular carcinoma [PDF]
Journal of Cancer Research and Clinical OncologyBackground Hepatocellular carcinoma (HCC) persists as a therapeutic challenge owing to restricted treatment alternatives and the dearth of effective biomarkers.
Wenfang Bao +5 more
doaj +3 more sources
SLC6A8 is a Potential Biomarker for Poor Prognosis in Lung Adenocarcinoma
Frontiers in Genetics, 2022 Background: Recent studies have demonstrated that creatine can promote tumor metastasis and has implications for immune cell function. SLC6A8 encodes a membrane protein that can transport creatine inside and outside the cell. However, there are currently
Xinwei Li, Yongfei Fan, Ming Lou
exaly +3 more sources
Frontiers in Genetics, 2022 There is mounting evidence on the implication of SLC6A8 in the initiation and progression of human cancers. However, a comprehensive understanding of the role of SLC6A8 in pan-cancer remains elusive yet.
Xin Yang, Qiao Li
exaly +3 more sources
Frontiers in Oncology, 2022 BackgroundStudies have demonstrated that the regulatory role of competitive endogenous RNA (ceRNA) networks is closely related to tumorigenesis, which provides new targets for tumor therapy. In this study, the focus was to explore the ceRNA networks that
Yongfei Fan, Zhaojia Gao, Ming Lou
exaly +3 more sources
Technology in Cancer Research and Treatment, 2020 Liver cancer is considered the sixth most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths worldwide. Currently, there is no specific and effective therapy for hepatocellular carcinoma.
Jianchu Wang, Jian Pu, Chenyi Zhuo
exaly +2 more sources
From extracellular entry to intracellular release: A water-assisted transport cycle for creatine in SLC6A8. [PDF]
Protein SciAbstract The creatine transporter (CRT/SLC6A8) plays a key role in cellular energy homeostasis, yet the molecular mechanism underlying creatine transport remains poorly understood. Here, we reconstruct the complete transport cycle of human CRT using a hybrid simulation strategy that combines constant‐force steered molecular dynamics (cf‐sMD) with ...
Poudel P, Panday SK, Alexov E.
europepmc +2 more sources
Multiple machine learning algorithms identified SLC6A8 as a diagnostic biomarker of the late stage of Hepatocellular carcinoma [PDF]
Discover OncologyHepatocellular carcinoma (HCC) is a chronic liver disease characterized by persistent tumor growth, contributing significantly to mortality rates worldwide.
Linlin Song, Hongli Zhang, Wang Yang
doaj +2 more sources
Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma [PDF]
Molecular OncologySquamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor‐initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis.
Johan Staaf +10 more
doaj +2 more sources