Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma [PDF]
Molecular OncologySquamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor‐initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis.
Johan Staaf +10 more
doaj +3 more sources
[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation [PDF]
Scientific ReportsPathogenic variants in the creatine transporter gene SLC6A8, reported to represent 2% of all intellectual disabilities in males, result in a spectrum of behavioral abnormalities including developmental delay, intellectual disability, and deficit in ...
Shili Xu +2 more
exaly +3 more sources
The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression [PDF]
Advanced ScienceCancer‐associated fibroblasts (CAFs) dominate the tumor stroma in colorectal cancer (CRC), fostering an immunosuppressive microenvironment that supports tumor growth, metastasis, and therapy resistance.
Jiahua Yu +5 more
doaj +3 more sources
Evaluation of SLC6A8 species conservation and the effect of pathogenic variants on creatine transport [PDF]
Human Genetics and Genomics AdvancesSummary: Creatine phosphate is a high-energy molecule essential for the normal functioning of highly metabolically active organs and tissues. SLC6A8 encodes the only known creatine transporter in humans (CRT1); pathogenic variants result in a ...
Gerald S Lipshutz
exaly +4 more sources
Frontiers in Genetics, 2022 There is mounting evidence on the implication of SLC6A8 in the initiation and progression of human cancers. However, a comprehensive understanding of the role of SLC6A8 in pan-cancer remains elusive yet.
Li Qiao
exaly +3 more sources
SLC6A8 is a Potential Biomarker for Poor Prognosis in Lung Adenocarcinoma
Frontiers in Genetics, 2022 Background: Recent studies have demonstrated that creatine can promote tumor metastasis and has implications for immune cell function. SLC6A8 encodes a membrane protein that can transport creatine inside and outside the cell. However, there are currently
Yongfei Fan, Zhaojia Gao, Xinwei Li
exaly +3 more sources
Targeting SLC6A8 suppresses tumor growth and enhances ferroptosis in hepatocellular carcinoma [PDF]
Journal of Cancer Research and Clinical OncologyBackground Hepatocellular carcinoma (HCC) persists as a therapeutic challenge owing to restricted treatment alternatives and the dearth of effective biomarkers.
Wenfang Bao +5 more
doaj +2 more sources
Frontiers in Oncology, 2022 BackgroundStudies have demonstrated that the regulatory role of competitive endogenous RNA (ceRNA) networks is closely related to tumorigenesis, which provides new targets for tumor therapy. In this study, the focus was to explore the ceRNA networks that
Yongfei Fan, Xinwei Li, Zhaojia Gao
exaly +3 more sources
Rougan Tongluo Decoction Initiates Neuroprotection Against Cerebral Ischemia by Activating the Endogenous SLC6A8‐Creatine‐EARS2 Mitochondrial Pathway [PDF]
Mediators of Inflammation, Volume 2026, Issue 1, 2026.Objective The traditional Chinese medicine formula Rougan Tongluo Decoction (RGTL) was widely used to treat neurological injury after cerebral ischemia, though its specific underlying mechanisms remain unknown. This study investigates the mechanisms via which RGTL helps alleviate cerebral ischemic injury to provide theoretical support for its ...
Changze Ou +6 more
wiley +2 more sources
Assessing Allele Frequency Information: A Study of Variant Curation Expert Panel Guidelines [PDF]
Human Mutation, Volume 2026, Issue 1, 2026.Purpose The 2015 guidelines recommend using a large, diverse, and race‐matched reference database. However, defining expectations in this context is subjective due to factors like genetic diversity and penetrance. ClinGen forms VCEPs to provide gene‐specific interpretations of ACMG/AMP guidelines, including population information.
Xiaoyan Wang +7 more
wiley +2 more sources