Results 71 to 80 of about 1,836 (142)

Evaluating Transcriptomic Biomarkers for rHuEPO Detection: Assessing the Impact of Exercise and Altitude Exposure

Drug Testing and Analysis, Volume 18, Issue 4, Page 581-602, April 2026.
A two‐stage transcriptomic filter comparing rHuEPO, exercise and altitude responses reduced 153 candidate genes to 50 that were unaffected by physiological stimuli. These retained transcripts offer focused biomarker leads to strengthen antidoping detection of rHuEPO.
Daria Obratov, Shaun Sutehall, Longhua Liu, Zhao Zhongying, Yannis Pitsiladis   +4 more
wiley   +1 more source

The skeletal muscle–adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management

Experimental Physiology, Volume 111, Issue 4, Page 1700-1707, 1 April 2026.
Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su, Na Liu, Yang Liu, Yiqun Sun, Yike Jiao   +4 more
wiley   +1 more source

Surface Potential-Engineered Dentin Promotes Jaw Repair Via Metabolic Reprogramming

International Dental Journal
Aim or purpose: To investige the immunoregulatory role of electroactive dentin in jaw repair, and establish its structure-function relationship with surface potential characteristics.
Yilin Zhang, Lisha Gu
doaj   +1 more source

Optimal neuromuscular performance requires motor neuron phosphagen kinases

The Journal of Physiology, Volume 604, Issue 5, Page 2027-2059, 1 March 2026.
Abstract figure legend Motor neuron (MN) terminals in fruit flies, mice and humans contain phosphagen kinases, a key enzyme in their energy storage and buffering system. Here we knocked down the primary phosphagen kinase in fruit fly larvae (arginine kinase 1 (ArgK1)) but were surprised to find that MN endurance was unaffected.
Karlis A. Justs, Danielle V. Latner (nee Riboul), Carlos D. Oliva, Yosuf Arab, Gabriel G. Bonassi, Olena Mahneva, Sarah Crill, Sergio Sempertegui, Paul A. Kirchman, Yaouen Fily, Gregory T. Macleod   +10 more
wiley   +1 more source

Síndromes de Deficiência Cerebral de Creatina

Acta Médica Portuguesa, 2013
Introdução: As síndromes de deficiência cerebral de creatina (OMIM 300036) são um grupo de patologias recentemente descritas,caracterizadas por defeitos congénitos no metabolismo da creatina.
Rui Malheiro, Luísa Diogo, Paula Garcia, Isabel Fineza, Guiomar Oliveira   +4 more
doaj   +1 more source

tRF‐30‐FP18LPMBQ4NK in Systemic Juvenile Idiopathic Arthritis: A Promising Diagnostic and Disease Activity Biomarker

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
ABSTRACT Diagnosing systemic juvenile idiopathic arthritis (sJIA) poses significant challenges. Accumulating evidence has indicated that tRNA‐derived fragments (tRFs) play integral roles in the pathogenesis of numerous diseases. Plasma samples were collected from individuals diagnosed with sJIA and healthy controls (HCs) from two medical centers and ...
Jiqian Huang, Yuting Pan, Jing Jin, Xiaoyan Shao, Wenjie Zheng, Zhidan Fan, Haiguo Yu   +6 more
wiley   +1 more source

Language disorder with mild intellectual disability in a child affected by a novel mutation of SLC6A8 gene

, 2011
We describe the clinical and molecular features of a child harboring a novel mutation in SLC6A8 gene in association with a milder phenotype than other creatine transporter (cri) deficient patients (OMIM 300352) [1-7]. The mutation c.757 G>C p.G253R in
Battini R, Chilosi A M, Moro F, Casarano M, Cioni G, Leuzzi V, Comparini A, Tosetti M, Alessandri M G   +8 more
core   +2 more sources

Upregulation and epigenetic modification of the creatine transporter SLC6A8 in non-small cell lung cancer [PDF]

Introduction. Lung cancer is a major cause of cancer-related death worldwide and effective therapies, besides surgery, are available only for a small proportion of patients.
Watermann, Christian, Fischer, Rieke N., Scheel, Andreas H., Perner, Sven, Drömann, Daniel, Kuempers, Christiane, Schnepf, Karoline, Marwitz, Sebastian, Ammerpohl, Ole, Goldmann, Torsten   +9 more
core  

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Epigenetic alterations in creatine transporter deficiency: a new marker for dodecyl creatine ester therapeutic efficacy monitoring

Frontiers in Neuroscience
Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the Slc6a8 gene. The impaired creatine uptake in the brain leads to developmental delays with intellectual disability.
Léa Broca-Brisson, Clémence Disdier, Rania Harati, Rania Harati, Rifat Hamoudi, Rifat Hamoudi, Rifat Hamoudi, Rifat Hamoudi, Rifat Hamoudi, Rifat Hamoudi, Aloïse Mabondzo   +10 more
doaj   +1 more source