Results 201 to 210 of about 49,955 (299)

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

Negative allosteric modulator of the metabotropic glutamate receptor 7 ADX71743 increases wakefulness, reduces sleep, and alters stress-induced changes in the brain neurotransmitter levels. [PDF]

Int J Neuropsychopharmacol
Kalinichev M, Gruner JA, Flik G, Heins M, Haddouk H, Royer-Urios I, Bate ST, Poli S, Lütjens R.   +8 more
europepmc   +1 more source

Sleep and cardiac autonomic modulation in older adults: Insights from an at‐home study with auditory deep sleep stimulation

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary The autonomic nervous system regulates cardiovascular activity during sleep, likely impacting cardiovascular health. Aging, a primary cardiovascular risk factor, is associated with cardiac autonomic disbalance and diminished sleep slow waves. Therefore, slow waves may be linked to aging, autonomic activity and cardiovascular health. However, it
Stephanie Huwiler, M. Laura Ferster, Luzius Brogli, Reto Huber, Walter Karlen, Caroline Lustenberger   +5 more
wiley   +1 more source

High-resolution sleep fragmentation assessment in narcolepsy type 1 and their non-narcoleptic siblings: a 5-s mini-epoch study. [PDF]

Sleep
Follin LF, Viste R, Vevelstad J, Langdalen K, Hansen BH, Grande RKB, Kaufmann T, Christensen JAE, Zahid AN, Viken MK, Juvodden HT, Knudsen-Heier S.   +11 more
europepmc   +1 more source

Profiling the sleep architecture of ageing adults using a seven‐state continuous‐time Markov model

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep is a complex biological process regulated by networks of neurons and environmental factors. As one falls asleep, neurotransmitters from sleep–wake regulating neurones work in synergy to control the switching of different sleep states throughout the night. As sleep disorders or underlying neuropathology can manifest as irregular switching,
Jonathon Jacobs, Caitlin E. Martin, Bernard Fuemmeler, Shanshan Chen   +3 more
wiley   +1 more source

The median preoptic nucleus is a key site for estradiol regulation of sleep-wake behaviors in females rats. [PDF]

Sleep
Kruk K, Smith PC, Cusmano DM, Viechweg SS, Byrd C, Huddleson A, Schwartz MD, Mong JA.   +7 more
europepmc   +1 more source

Respiratory safety of lemborexant in adult and elderly subjects with moderate‐to‐severe chronic obstructive pulmonary disease

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Lemborexant 10 mg, a dual orexin‐receptor antagonist (DORA), did not elicit respiratory depressant effects, as measured by peripheral oxygen saturation (SpO2) or apnea–hypopnea index (AHI), in subjects with moderate‐to‐severe chronic obstructive pulmonary disease (COPD).
Jocelyn Y. Cheng, Daniel Lorch, Nancy Hall, Margaret Moline   +3 more
wiley   +1 more source

Sexsomnia in a Young Man: A Non-REM Parasomnia With Diagnostic and Therapeutic Challenges. [PDF]

Am J Case Rep
Almutairi MB, Alhomayin LA, Alshahrani MM.   +2 more
europepmc   +1 more source

Dreaming conundrum

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Dreaming, a common yet mysterious cognitive phenomenon, is an involuntary process experienced by individuals during sleep. Although the fascination with dreams dates back to ancient times and gained therapeutic significance through psychoanalysis in the early twentieth century, its scientific investigation only gained momentum with the ...
Carlotta Mutti, Francesca Siclari, Ivana Rosenzweig   +2 more
wiley   +1 more source

Unmasking the Prodrome: A Deep-Learning Bridge to Precision Diagnostics in Rapid Eye Movement Sleep Behavior Disorder. [PDF]

J Clin Neurol
Kwon KY.
europepmc   +1 more source