Results 131 to 140 of about 692,660 (248)

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Does COVID-19 Infection Continue to Affect Self-Reported and Objective Sleep? A Longitudinal Study of Good Sleepers

Nature and Science of Sleep
Jun Wu,1– 3 Baixin Chen,1– 3 Qingsong Qin,4 Yanyuan Dai,1– 3 Le Chen,1– 3 Dandan Zheng,1– 3 Jiansheng Zhang,1– 3 Yun Li1– 3 1Department of Sleep Medicine, Mental Health Center of Shantou University, Shantou, Guangdong, People’s Republic of China; 2Sleep ...
Wu J, Chen B, Qin Q, Dai Y, Chen L, Zheng D, Zhang J, Li Y   +7 more
doaj  

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source

Pain-induced sleep disturbances fully mediate the association between symptomatic hip and knee osteoarthritis and poor sleep quality : a cross-sectional study. [PDF]

Bone Jt Open
Sorel JC, Korterink BHW, Noordam R, Rosendaal FR, Kloppenburg M, Nelissen RGHH, le Cessie S, Poolman RW, Broekman BFP, Gademan MGJ, LOAS and NEO study group.   +10 more
europepmc   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Psychometric properties of the two-item Pittsburgh Sleep Quality Index (PSQI-2) in a cohort of community-dwelling older men: the MrOS sleep study. [PDF]

NPJ Biol Timing Sleep
Menezes-Júnior L.
europepmc   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

49 A pilot meta-analysis on concussion-related sleep disturbances

BMJ Open Respiratory Research, 2021
Yizhou Yu, Connor Qiu, Suleyman Noordeen, Mehmet Ergisi, Rebeka Popovic, Abinayan Mahendran, Mohammed Memon, Saahil Hegde, Poh Wang   +8 more
doaj   +1 more source

Advancing Precision Nutrition Through Multimodal Data and Artificial Intelligence

Advanced Science, EarlyView.
Individual responses to food vary dramatically, challenging traditional dietary advice. This review explores how the unique genetic makeup, gut microbiome, and brain activity shape host metabolic health. We examine how artificial intelligence integrates these multimodal data to predict individualized dietary needs, moving beyond one‐size‐fits‐all ...
Yuanqing Fu, Ke Zhang, Zelei Miao, Gaoyi Yang, Yujing Huang, Ju‐Sheng Zheng   +5 more
wiley   +1 more source

Sex-specific effects of naturally shorter sleep on experimental pain perception. [PDF]

Pain Rep
Rouhi S, Jordan AS, Egorova-Brumley N.
europepmc   +1 more source