Results 231 to 240 of about 106,405 (314)
ABSTRACT Background Patients undergoing palatoplasty experience perioperative adverse events. Identifying risk factors for perioperative adverse events and escalation of care may improve outcomes. Methods Pediatric patients undergoing primary palatoplasty were included in this retrospective observational study performed at two academic children's ...
Febina Padiyath +17 more
wiley +1 more source
Codeine and Metabolite Concentrations in the Breastfed Neonate
ABSTRACT Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O‐demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified. This spectrum of polymorphism can be categorized into four groups: poor (PM), intermediate (IM), normal (NM),
Brian J. Anderson, Jacqueline A. Hannam
wiley +1 more source
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan +9 more
wiley +1 more source
Abstract Background Spinal cerebrospinal fluid (CSF) leaks, a rare but debilitating condition, have been described following spinal manipulative therapy (SMT) in case reports. However, the nature of the potential association between SMT and CSF leak is uncertain, and symptoms such as neck pain or headache may reflect preexisting leaks rather than ...
Robert J. Trager +4 more
wiley +1 more source
Objective sleep parameters and diurnal blood pressure in concurrent hypertension and type 2 diabetes
Abstract Background Hypertension is a primary cardiovascular complication in type 2 diabetes associated with increased morbidity and mortality. Ambulatory blood pressure monitoring (ABPM) is essential for capturing circadian BP variation, which is closely influenced by sleep. Methods Twenty patients (63.75 ± 4.44 years old, 40% female, duration of T2D:
Yan Zhao +6 more
wiley +1 more source
Abstract Purpose This study aimed to analyze the effectiveness of sleep apnea‐specific hypoxic burden (SASHB) and sleep disordered breathing index (SBII) in assessing cognitive dysfunction in adults with obstructive sleep apnea (OSA) and to compare them with the apnea‐hypopnea index (AHI).
Zitong Wang +15 more
wiley +1 more source
Abstract Study Objectives Obesity is a major determinant of obstructive sleep apnea (OSA) severity, but its influence may vary across adulthood. We examined age‐related patterns of body mass index (BMI), apnea–hypopnea index (AHI), and hypoxemic burden, and assessed whether the association between BMI and OSA severity attenuates with age.
Peretz Lavie
wiley +1 more source

