Results 111 to 120 of about 713,881 (334)

Sleep and Psychiatric Disorder [PDF]

, 1968
James A. Ward
openalex   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Sleep Disorders Classification Committee, Association of Sleep Disorders Centers [PDF]

, 1979
P. Roffwarg Howard
openalex   +1 more source

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis

Advanced Science, EarlyView.
The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang, Yuxin Zhang, Simo Xia, Lu Chen, Pei Shen, Chi Yang   +5 more
wiley   +1 more source

Sleep Spindle Activity Changes in Patients With Affective Disorders [PDF]

, 1987
Viviane De Maertelaer, Orsolya Hoffman, Mathieu Lemaire, Julien Mendlewicz   +3 more
openalex   +1 more source

Calcitonin Gene‐Related Peptide (CGRP)‐Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain‐Induced Sleep Disturbances

Advanced Science, EarlyView.
Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch, Roberto De Luca, Richard L Spinieli, Enrico Rillosi, Renner C Thomas, Samuel Sailesh, Nishta Gangeddula, Janayna D Lima, Sathyajit S Bandaru, Elda Arrigoni, Agustin Melo‐Carrillo, Rami Burstein, Stephen Thankachan, Satvinder Kaur   +13 more
wiley   +1 more source

Evaluation of daytime sleepiness and insomnia symptoms in OSA patients with a characterization of symptom-defined phenotypes and their involvement in depression comorbidity—a cross-sectional clinical study

Frontiers in Psychiatry
IntroductionRecent research highlights the significance of insomnia and sleepiness, shifting from obstructive sleep apnea (OSA) severity and sleep structure, in defining OSA phenotypes.ObjectivesThis study aimed to characterize insomnia and sleepiness ...
Agata Gabryelska, Szymon Turkiewicz, Piotr Białasiewicz, Filip Grzybowski, Dominik Strzelecki, Marcin Sochal   +5 more
doaj   +1 more source

Sleep Disorders, Insomnia and Narcolepsy [PDF]

, 1982
Colin Murray Parkes
openalex   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C

Advanced Science, EarlyView.
The release of COL6A3 by fibroblasts is sensed by the CD44 receptor on melanocytes, activating glutathione (GSH) metabolism and increasing melanocyte survival during skin organoid culture. SEMA3C released by bulge cells binds to the NRP1 receptor on melanocytes, regulating microtubule stability and promoting melanocyte recruitment and function during ...
Tingting Li, Xinzhu Li, Xiao Xiang, Jundong Huang, Xinyu Shen, Mengyue Wang, Jingwei Jiang, Shiwen Shao, Zeming Li, Tian Xie, Deming Liu, Yiping Zhao, Rui Ma, Wenyu Wu, Wei Shi, Cheng‐Ming Chuong, Ji Li, Mingxing Lei   +17 more
wiley   +1 more source