Results 81 to 90 of about 142,295 (263)

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

Sleep disturbances and nightmares in victims of sexual abuse with post-traumatic stress disorder: an analysis of abuse-related characteristics

European Journal of Psychotraumatology, 2019
Background: Sexual abuse victims often experience symptoms of post-traumatic stress disorder (PTSD), including sleep disturbances. Objective: To investigate whether or not characteristics of sexual abuse are associated with sleep disturbance, and to ...
Geneviève Belleville, Mylène Dubé-Frenette, Andréanne Rousseau   +2 more
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Sleep in adolescents and young adults with type 1 diabetes: associations with diabetes management and glycemic control

Health Psychology and Behavioral Medicine, 2016
Objective: To describe sleep in adolescents and young adults with type 1 diabetes (T1D) and explore the association between sleep disturbances, diabetes management and glycemic control. Methods: Adolescents with T1D (n = 159, mean age = 16.4, 43% female,
Sarah S. Jaser, Deborah Ellis
doaj   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Sleep problems and sensory features in children with low-average cognitive abilities and autism spectrum disorder

Scientific Reports
Children with Autism Spectrum Disorder (ASD) often have more sleep disturbances than typically developing children. These sleep disturbances have been suggested to be associated with atypical sensory features in children with ASD.
Sumie Iwasaki, Yuko Yoshimura, Chiaki Hasegawa, Sanae Tanaka, Takashi Ikeda, Ken Yaoi, Tetsu Hirosawa, Mitsuru Kikuchi   +7 more
doaj   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

The relationship between anemia and sleep disturbances among older Chinese adults: The mediating role of handgrip strength.

PLoS ONE
BackgroundSleep plays an important role in human health, and anemia can lead to a continuous deterioration of sleep. However, the association and mechanism between anemia and sleep disturbances remain unclear. This study aimed to examine the relationship
Jie Li, Zunyi Ma, Xiaojiang Zhao
doaj   +1 more source

Subjective and objective sleep disturbances following trauma-focused treatment

European Journal of Psychotraumatology
Background: Most individuals with posttraumatic stress disorder (PTSD) report sleep disturbances. Yet, results on the impact of trauma-focused therapy on subjective and objective sleep disturbances are inconsistent.Objectives: This study conducted ...
Salomé Porten, Franziska Friedmann, Nikola Schoofs, Charlotte Barth, Kristina Meyer, Philip Santangelo, Ulrich Ebner-Priemer, Meike Müller-Engelmann, Regina Steil, Nikolaus Kleindienst, Frank Enning, Thomas Fydrich, Kathlen Priebe   +12 more
doaj   +1 more source