Results 41 to 50 of about 6,976,483 (208)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Sleep Apnea and Quality of Life [PDF]
Sleep, 2000 To investigate the effects of sleep apnea (SA) on the quality of life (QOL).A prospective study of QOL in patients with and without SA as defined by an apnea-hypopnea index (AHI) >5.University-based outpatient clinics.Primary care patients followed in a general internal medicine clinic as well as those referred to a sleep disorders clinic at the ...
E H, Yang +5 more
openaire +2 more sources
The role of sleep in the psychological functioning of adolescents [PDF]
, 2016 Adolescents’ sleep is related to psychological functioning. The present cumulative dissertation examined three main issues: First, whether parents’ sleep patterns are associated with their adolescent children’ sleep Patterns using objective assessment of
Kalak, Nadeem
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Sleep quality and obstructive sleep apnea in pregnant women
International Journal of Preventive Medicine, 2015 DEAR EDITOR, One of the common disorders during pregnancy is sleep-disordered breathing (SDB).[1] SDB includes snoring, upper airway resistance syndrome, and obstructive sleep apnea (OSA)-hypopnea syndrome.[1] Snoring is considered as a risk factor for adverse pregnancy outcomes, including fetal heart rate abnormalities, fetal demise, fetal ...
Mahsa Ghajarzadeh +4 more
openaire +3 more sources
Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
Subjective sleep, depression and anxiety: inter-relationships in a non-clinical group [PDF]
, 2009 Objectives Previous research confirms the interdependent relationship between poor sleep and depression, but has often focused on objective measures of sleep and overlooked the importance of subjective factors.
Mayers, Andrew G. +8 more
core +1 more source