Results 71 to 80 of about 438,394 (315)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Relationship between sleep quality, chronotype, and depression in youth: A cross-sectional study [PDF]

Aims: In today’s electronic age, the frequency of both poor sleep quality and the evening chronotype are increasing and are associated with numerous adverse physical and mental health outcomes. This study was conducted on a group of healthy Turkish youth
Necla İpar
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Sleep quality and related factors among healthcare workers in designated quarantine hospital site in post-pandemic based on the health ecological model: a cross-sectional study in Nanjing, China

Frontiers in Public Health
AimsThis study aims to assess the status and related factors among healthcare workers (HCWs) in designated quarantine-hospital-site (DQHS) based on the model of health ecology.MethodsThe cross-sectional study was conducted from April to May, 2022, which ...
Han Zhou, Lei Shen, Huafeng Tan, Jiefang Zhou, Qiyi Zheng, Dongdong Jiang   +5 more
doaj   +1 more source

The relationship between sleep status and activity of daily living: based on China Hainan centenarians cohort study

BMC Geriatrics, 2023
Objective This study, based on the China Hainan Centenarians Cohort Study (CHCCS), aims to comprehensively describe the characteristic of daytime, night and total sleep duration, sleep quality and different sleep mode of Hainan centenarians and their ...
Shanshan Yang, Shengshu Wang, Guangdong Liu, Rongrong Li, Xuehang Li, Shimin Chen, Yali Zhao, Miao Liu, Yunxi Liu, Yao He   +9 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

The association between noise, work stress and coping with sleep quality among cable manufacturing workers [PDF]

, 2018
Poor sleep quality has been found previously to cause various negative outcome among workers. There are many factors which may influence sleep quality which include noise and work stress.
Rasdi, Irniza, Fadzil, Fara Fadila
core  

Sleep quality and obstructive sleep apnea in pregnant women

International Journal of Preventive Medicine, 2015
DEAR EDITOR, One of the common disorders during pregnancy is sleep-disordered breathing (SDB).[1] SDB includes snoring, upper airway resistance syndrome, and obstructive sleep apnea (OSA)-hypopnea syndrome.[1] Snoring is considered as a risk factor for adverse pregnancy outcomes, including fetal heart rate abnormalities, fetal demise, fetal ...
Mahsa Ghajarzadeh, Fariba Askari, Mona Mohseni, Mehdi Mohammadifar, Behzad Memari   +4 more
openaire   +3 more sources

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source