Results 151 to 160 of about 178,510 (288)

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Missense Variants in the A Isoform of FGF13 as a Novel Cause of Paroxysmal Dyskinesia

Movement Disorders, EarlyView.
Abstract Background Pathogenic variants within the unique N‐terminal inactivation particle of FGF13 isoform A (FGF13A) have so far been associated only with an X‐linked dominant epileptic encephalopathy (DEE). Objective The aim was to expand the clinical and molecular spectrum of FGF13A‐related disorder.
Cyril Mignot, Matthildi Athina Papathanasiou Terzi, Claudia Ravelli, Elisabeth Bosch, Xueqin Lin, Adeline Trauffler, Roseline Caumes, Andrew E. Fry, Clementine Fort, Gaelle Gauthe, Regina Trollmann, Thomas Wirth, Mathieu Anheim, Aurélie Méneret, Emmanuel Roze, Jean‐Madeleine de Sainte Agathe, Hailan He, Eleni Panagiotakaki, Gaëtan Lesca, André Reis, Diane Doummar, Thomas Smol, Georgia Vasileiou   +22 more
wiley   +1 more source

The Lesson of Sleeping Beauty: Person-Centred Care for the Unconscious, Unresponsive ICU Patient in the Face of Levinas' Radical Alterity. [PDF]

Nurs Philos
Clement T, Zeillinger PA, Mayer H, McCormack B.   +3 more
europepmc   +1 more source

Large-scale analysis of delayed recognition using sleeping beauty and the prince. [PDF]

Appl Netw Sci, 2021
Miura T, Asatani K, Sakata I.
europepmc   +1 more source

Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation

Movement Disorders, EarlyView.
Abstract Adaptive deep brain stimulation (aDBS) represents an important evolution in the treatment of Parkinson's disease (PD), building on conventional DBS (cDBS) by adjusting stimulation in response to real‐time physiological signals. By enabling dynamic targeting of disease‐related neural activity, aDBS offers the potential for more precise ...
Thomas Koeglsperger, Maximilian Scherer, Andrea A. Kühn, Alexandre Eusebio, Alfonso Fasano, Joachim K. Krauss   +5 more
wiley   +1 more source

Jumping Ahead with Sleeping Beauty: Mechanistic Insights into Cut-and-Paste Transposition. [PDF]

Viruses, 2021
Ochmann MT, Ivics Z.
europepmc   +1 more source

A novel hyperactive variant of the Sleeping Beauty transposase facilitates non-viral genome engineering. [PDF]

Mol Ther Nucleic Acids
Ochmann MT, Miskey C, Botezatu L, Sandoval-Villegas N, Diem T, Ivics Z.   +5 more
europepmc   +1 more source

Molecular and Functional Characterization of BDNF-Overexpressing Human Retinal Pigment Epithelial Cells Established by Sleeping Beauty Transposon-Mediated Gene Transfer. [PDF]

Int J Mol Sci, 2022
Mattern L, Otten K, Miskey C, Fuest M, Izsvák Z, Ivics Z, Walter P, Thumann G, Johnen S.   +8 more
europepmc   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Optimized GMP-grade production of non-viral Sleeping Beauty-generated CARCIK cells for enhanced fitness and clinical scalability. [PDF]

J Transl Med
Pisani I, Melita G, de Souza PB, Galimberti S, Savino AM, Sarno J, Landoni B, Crippa S, Gotti E, Cuofano C, Pedrini O, Capelli C, Matera G, Belotti D, Cesana S, Cabiati B, Quaroni M, Colombo V, Mazza M, Vergani B, Gaimari A, Nicolini F, Tazzari M, Bocchini M, Serafini M, Rambaldi A, Rambaldi B, Dastoli G, Biondi A, Gaipa G, Introna M, Golay J, Tettamanti S.   +32 more
europepmc   +1 more source